Prostate Flashcards

1
Q

LUTS symptoms / IPSS questionnaire = international prostate symptom score

A
Incomplete emptying
Frequency
intermittency
Urgency
Weak stream
Straining
Nocturia
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2
Q

LUTS - more likely to be BPH or cancer?

A

BPH affects urethra more quickly than cancer

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3
Q

Voiding vs storage problems

A
Voiding = 
Hesitancy
Weak stream
Intermittency 
Incomplete emptying 

Storage symptoms:
Frequency
Urgency
Nocturia

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4
Q

What might cause voiding symptoms?

A
BPH
Urethral stricture (in young men)
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5
Q

What might cause storage symptoms?

A

Detrusor overactivity

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6
Q

Investigations

A
Frequency volume chart
Haematuria
DRE
Urine flow check 
Urine dpstick
Flow rate
Bladder scan
u and e psa
renal USS
Cystoscopy to check for strictures
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7
Q

What objects are used to estimate sizes of the prostate?

A

Ping pong ball size

Tennis ball

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8
Q

What conservative and medical management

A

Conervative - reassure and advice on fluid intake

Medical:

Alpha blockers - tamsulosin, alfuzosin

5 alpha reductase inhibitors - finasteride, dutasteride

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9
Q

Herbal meds for BPH

A

Saw palmetto

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10
Q

Surgical management for BPH

A

TURP - trans urethral resection of prostate

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11
Q

Other options for managing BPH

A

Laser surgery
Rezum/steam
urolift - stapling lobes of prostate to side
Embolisation (for elderly if not fit for spinal anaesthetic)
Long term catheter

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12
Q

5 alpha reductase inhibitors

A

Finasteride, dutasteride

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13
Q

Alpha blockers

A

Tamsulosin, alfuzosin

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14
Q

Treatment of overactive bladder - conservative

A

Reassure
Bladder training exercises (BAUS)
Dietary advice

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15
Q

Treatment of medical management for overactive bladder

A

Anticholinergics

Beta agonist

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16
Q

Anticholinergics used for overactive bladder

A

Oxybutinin
Tolterodine
Solifenacin

17
Q

Beta agonist used for overactive bladder

18
Q

Surgical management of used for overactive bladder

A

Botox to knock out detrusor

But wears off after 6 month

19
Q

Risk factor for prostate cancer

A

Afrocarribean males

BRCA2 genes

20
Q

A PSA over what range gets investigated

A

Anyone with a PSA over 3

21
Q

Causes of raised PSA

A
BPH
Urinary retention
Infection
Catheter
Prostate cancer
22
Q

What investigation does not cause a raised PSA

23
Q

What is used to GRADE the prostate cancer? What indicates low risk? What indicates high risk?

A

Gleason scoring system
3 + 3 low risk

5 + 5 high risk

24
Q

Investigations for prostate cancer

A

grading
Staging
MRI / bone scan
MDT discussion

25
Active surveillance is used for which patients with prostate cancer?
For young men
26
When would you do watchful waiting for prostate cancer? What do you do afterwards?
Elderly Co-morbid patients Delay hormonal treatment which cuts off testosterone until it is absolutely needed (as it you get menopausal treat
27
Main SE of prostate cancer therapy
Erectile difficulties | Incontinence
28
Radical radiotherapy is used for which patients with prostate cancer?
Higher PSAs | Older patients
29
Which of these treatments doesn't actually cure patients?
Hormones and chemo doesn't cure patients
30
Types of hormonal therapy for prostate cancer
Antiandrogen - blocks testosterone receptors directly | LHRH agonist - overstimulate pituitary
31
Why are antiandrogens started before the LHRH agonists?
Over production of testosterone initially due to LHRH agonistic activity Causes rapid fall of testosterone Wh
32
Why are antiandrogens started before the LHRH agonists?
Over production of testosterone initially due to LHRH agonistic activity So if someone has spinal mets, can make it worse So give antiandrogens first