Endo thyroid

Question 1

Treatment for hypothyroidism

Answer 1

Levothyroxine - 50 to 100 mcg once daily

Thyroxine - 100mcg

Question 2

Treatment for hyperthyroidism

Answer 2

Carbimazole 15-40mg OD

AND

Propranolol 20mg or 40mg TDS

Question 3

Hypopituitarism treatment

Answer 3

Levothyroxine
Testosterone - Nebido, 1g IM every three months OR oestrogen/HRT
Prednsiolone once daily or hydrocortisone TDS

Question 4

Why do you give pred over hydrocortisone?

Answer 4

Pred - longer half life

Question 5

What’s the problem with the TDS hydrocortisone treatment? What’s Nthe ew drug that mimicked the natura l

Answer 5

Ends up having three peaks, whereas the body actually has just one peak in teh morning then slowly decreases.

Plenadren - slow release hydrocortisone but not good if someone has problems with absorption or need cortisol quickly

Question 6

Fludrocortisone vs aldosterone

Answer 6

Has a fluorine attached to aldosterone, which means it has a slow half life due to difficulty breaking down

50 or 100 mcg depending on BP and potassium

Question 7

What drug actually mimics natural cortisol levels

Answer 7

1,2 dehydrohydrocortisone = double bond on cortisol, mimics ALSO CALLED PREDNISOLONE

Question 8

Dose of pred for addisons

Answer 8

3-4mg = one daily

Low dose so SE reduced!

Question 9

What’s the 2-4mg pred dose equivalent for hydrocortisone

Answer 9

Equivalent of 20mg hydrocortiosne??

Question 10

SE if you give 5mg pred

Answer 10

Weight gain
Osteoporosis
Adrenal suppression