Myeloma

Question 1

How might bone marrow failure present?

Answer 1

Anaemia
Infection
Bleeding from low platelet count

Question 2

If someone has acute myeloid leukemia with neutropenia, what might they present with?

Answer 2

Fatal gram negative septicemia

Question 3

If someone has lymphoid disease, what might they present with?

Answer 3

?

Question 4

Chronic myeloid vs chronic lymphoid

Answer 4

Hepatomegaly in both

Lymphadenopathy in lymphoid

Question 5

Lymphoid cancer presntation

Answer 5

IVC obstruction

infiltration of liver brain or eyes

Question 6

Systemic presentatios

Answer 6

Hypermetabolism
B symptoms - FLAWS
Tumour lysis syndrome - release of intracellular contents
Autoimmune disorders

Question 7

What are the two types of bone marrow biopsies?

Answer 7

Bone marrow aspirate

Bone marrow trephine - core of bone marrow

Question 8

?

Answer 8

Core biopsy - looks for cells that shouldn’t be there, e.g. TB or mets
However doesn’t tell you the architecture of the lymphoid tissue

Question 9

?

Answer 9

Flow cytometry
Immunohistochemistry
Architecture of tumour