Primary sclerosing Cholangitis Flashcards
1
Q
What is PSC
A
Autoimmune destruction of the hepatic ducts
2
Q
What are the RF for PSC
A
MALE (40-50)
IBD Link
3
Q
What is the pathology of PSC
A
Chronic Autoimmune granulomatous infalammation causing Cholestasis
4
Q
How does a patient with PSC present
A
Asymptomatic
Pruritis, fatigue, jaundice and Charcot’s Triad
IBD and Hepatosplenomegaly
5
Q
How is PSC investigated
A
Serology -HBV/HCV NEGATIVE -AMA NEGATIVE -anti TTG NEGATIVE (Coeliac screen) -pANCA positive Gold = MRCP
6
Q
What is the gold test for PSC
A
MRCP
7
Q
How is PSC Treated
A
URS Deoxychlic acid ineffective Conservative management -Cholestyramine for pruritis -Vit KADE -Liver transplant
8
Q
What is different about the associations of PBC and PSC
A
PBC = Female w/ Autoimmume disorder PSC = Male w/ IBD
9
Q
How does PSC present different to PBC
A
Both= Pruritis PSC = Fatigue and jaundice PBC = Charcot and IBD Signs
10
Q
How does the serology differ between PSC and PBC
A
PBC = AMA Positive PSC= pANCA positive
11
Q
Does URS Deoxycholic acid treat PSC or PBC
A
PBC
