Primary Biliary Cholangitis

Question 1

What is PBC

Answer 1

Hepatic Autoimmune jaundice affecting the Bile ducts

Question 2

What are the RF of PBC

Answer 2

Female (40-50)
Autoimmune disease
Smoking

Question 3

What is the pathology of PBC

Answer 3

Autoantibodies cause chronic granulomatous inflammation of the Bile ducts causing Cholestasis

Question 4

What are the presentations of PBC

Answer 4

Asymptomatic

Pruritis and Fatigue then Jaundice

Question 5

How is PBC Investgated

Answer 5

Raised LFT w/ low albumin
Rule out Hepatitis
Serology = AMA antibodies
1st = USS (exclude Extrahepatic Cholesatis)
Gold = Liver biopsy (Shows portal infiltration, Granulomas and fibrosis)

Question 6

What is the gold test for PBC and what does it show

Answer 6

PORTAL

• Infiltration
• Granuloma
• Fibrosis

Question 7

What is the first line treatment for PBC

Answer 7

URS Deoxycholic acid (Decrease cholesatsis)
If Pruritis = Colestyramine
Osteomalacia? Vit KADE
Liver transplant

Question 8

What is given to treat pruritis

Answer 8

Cholestyramine

Question 9

Why does pruritus appear as a symptom in liver diases

Answer 9

Excess Con bilirubin leaks to skin