Gilberts and Crigier Najjar Flashcards
1
Q
What is Gilberts
A
Autosomal recessive cause of hereditary jaundice
2
Q
What are the RF for gilberts
A
Male
T1DM
FHx
3
Q
What is the pathology of Gilberts
A
Abnormal UGT = Raised Unconj.Bilirubin
4
Q
What are the presentations of Gilberts
A
Asymptomatic
Painless jaundice at young age
5
Q
What is Crigier Najjar
A
Severe
Jaundice w/ N+V and lethargy
6
Q
How is Gilberts treated
A
No treatment required
7
Q
How is Crigier Najjar treated
A
Severe progression causing Kernicterus in childhood
8
Q
What is Kernicterus
A
Complication of Crigier Najjar
Bilirubin accumulation in basal ganglia
Neurological deficit
9
Q
How is Crigier Najjar treated
A
Phototherapy (Break down Unconj. Bilirubin)
