Prenatal testing for fetal aneuploidy

Question 1

Trimester 1

Answer 1

0-12 weeks

Question 2

Trimester 2

Answer 2

13-27 weeks

Question 3

Trimester 3

Answer 3

28-birth

Question 4

full term

Answer 4

40 weeks

Question 5

1st trimester combined test

Answer 5

Done at 9-13 wks

* pregnancy associated plasma protein A * BhCG * nuchal translucency

noninvasive/nondx

Question 6

cell-free fetal DNA

Answer 6

10+ weeks

screens: * trisomies * fetal sex
indications: * mom 35+ * previous abnormal serum/sono * hx of previous aneuploidy nondx

Question 7

Chorionic villus sampling

Answer 7

10-13 weeks

offers definitive karyotype

risk of spotting, pregn loss

Question 8

2nd trimester quadruple screen

Answer 8

15-20 weeks

* maternal serum alpha-fetoprotein * estriol * BhCG * inhibin A

noninvasive/nondx

Question 9

Amniocentesis

Answer 9

15-20 weeksdefinitive, high risk

Question 10

2nd trimester US

Answer 10

18-20weeks

learn: * fetal growth * fetal anatomy * placental position

considered “soft findings”

Question 11

2 tests done at 15-20 weeks?

Answer 11

2nd trimester quadruple screen & amnio

(2nd trimester US at 18-20wks)

Question 12

2nd trimester quadruple screen results

Answer 12

Question 13

Pregnancy associated Plasma protein A

Answer 13

9-14 weeks

a low risk screening for Trisomy21