Infectious Disease Flashcards
when to prophylax?
CD4+
less than 200: Pneumocystis jirovecci
less than 100: toxoplasmosis
less than 50: MAC
Prophylaxis and tx for Pneumocystis pneumonia?
- TMP-SMX
- Dapsone
- Atovoquone
- pentamidine
- clinda + primaquine
Prophylaxis and tx for toxo?
see ring-enhancing lesion on MRI
proph: TMP-SMX
tx: pyrimthamine/sulfadoxine + folate
Prophylaxis and tx for MAC?
this is AIDS diarrhea
proph: azithromycin
tx: clinda + ethambutol +/- rifampin
the 3 AIDS diarrheas?
- CMV
- MAC
- Cryptosporidium parvum
CMV?
AIDS diarrhea dx: coloscopy w/ biopsy - need to see intranuclear inclusions diarrhea +/- bloody tx: ganciclovir (AE: neutropenia) or foscarnet (AE: renal tox)
Cryptosporidium parvum?
AIDS diarrhea
dx: see acid fast oocysts
watery/mucousy diarrhea
A solitary ring enhancing lesion that doesnt get better with toxo tx?
Can be CNS lymphoma
assc with EBV
AIDS pt with seizure and deja-vu aura?
HSV encephalitis
see bloody lumbar puncture
likes the temporal lobe
tx: acyclovir ASAP
AIDS meningitis
mc: s. pneumo
opportunistic: cryptococcus neoformans
tx for cryptococcus = amphotericin IV 2wks, then fluconazole
cryptococcus neoformans vs cryptosporidium parvum
neoformans = AIDS meningitis (stains + with india ink) parvum = AIDS diarrhea ("acid fast oocysts)
Use this for dental endocarditis prophylaxis
what are the indications for dental endocarditis proph?
need proph if: hx of prosthetic valve/valve replaced, hx of endocarditis, or hx of uncorrected congen heart lesion
proph with amoxicillin
Does coccidioides need prophylaxis?
no. not according to UpToDate
tx: clinda + ethambutol +/- rifampin?
MAC diarrhea
tx: pyrimethamine/sulfadoxine + folate?
toxo