premature ovarian insufficiency Flashcards
1
Q
what
A
menopause< 40yrs
2
Q
characterised by
A
hypergonadotropic hypogonadism
3
Q
hormonal analysis will show
A
raised FSH, LH
low oestrogen
4
Q
causes
A
idiopathic iatrogenic - chemo, surgery autoimmune - coeliac, T1DM, adrenal insuff, thyroid genetic - FHx, Turner's syndrome infections - mumps, TB, CMV
5
Q
presentation
A
irreg menstrual cycles 2ry amenorrhoea hot flushes night sweats vaginal dryness
6
Q
diagnosis
A
women <40yrs with typical menopause symptoms plus elevated FSH
FSH should be persistently >25 on 2 consecutive samples >4wks apart
7
Q
women with premature ovarian failure are at higher risk of X due to lack of oestrofen
A
cardiovascular disease stroke osteoporosis cognitive impairment dementia parkinsonism
8
Q
Mx
A
HRT until at least usual age menopause
- traditional HRT
- COCP
