PCOS Flashcards

1
Q

characteristic features of

A
multiple ovarian cysts
infertility 
oligomenorrhoea
hyperandrogenism 
insulin resistance
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2
Q

androgens

A

male sex hormones - testosterone

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3
Q

hirsutism

A

growth of thick dark hair often in a male pattern

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4
Q

Rotterdam criteria

A

2/3 of

  • oligoovulation/anovulation presenting with irreg/absent periods
  • hyperandrogenism - hirsutism and acne
  • polycystic ovaries on USS
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5
Q

presentation

A
oligomenorrhoea/amenorrheoa
infertility 
obesity 
hirsutism 
acne 
hair loss in male pattern 
insulin resistance
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6
Q

Ix - nice recommended blood tests

A
testosterone
sex hormone binding globulin
LH 
FSH 
prolactin 
TSH
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7
Q

hormonal analysis shos

A

raised LH
raised LH:FSH ratio
raised testosterone
raised insulin

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8
Q

LH and FSH levels

A

LH raised

LH raised more than FSH giving high ratio

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9
Q

gold standard for visualising ovaries

A

transvaginal USS

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10
Q

transvaginal USS - findings

A

string of pearls appearance

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11
Q

transvaginal USS - diganostic criteria

A

12+ developing follicles in one ovary
or
ovarian volume >10cm3

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12
Q

PCOS - screening test for diabetes

A

OGTT

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13
Q

OGTT results - impaired fasting glucose

A

fasting Gcl of 6.1-6.9

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14
Q

OGTT results - impaired glucose tolerance

A

plasma Glc at 2 hrs - 7.8-11.1

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15
Q

OGTT results - diabetes

A

plasma Glc at 2hrs >11.1

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16
Q

Mx -general

A
weight loss
low glycaemic index
exercise
stop smoking 
antihtn if needed
statin where indicated
17
Q

Mx- reducing risk endometrial cancer

A

mirena coil

inducing withdrawal bleed every 3-4 months with POP, COCP

18
Q

Mx - infertility

A

weight loss
clomifene
laparoscopic ovarian drilling
IVF

19
Q

Mx - hirsutism

A

weight loss
COCP - co-cyprindiol
topical eflornuthine

20
Q

Mx - acne

A
  1. COCP

topical adapalene
topical antib
topical azelaic acid