Practice exam 2 Flashcards
Sturge Weber syndrome
- distribution?
Associated with Port Wine Stain where 10-15% of the capillary malformation is V1 distribution. Thus can casue ocular (glaucoma) and neurologic abnormalities (seizures)
What would you use to treat infantile hemangioma?
It has lots of complications remember?
Treat with Beta blockers to decrease angiogenesis
Which of benign tumors originates from oil glands?
Sebaceous hyperplasia
*note: Common. Increases frequency after middle age. Could be sunlight induced. Distributes face >trunk> extremities
p53
tumor suppressor
Skin diseases due to defect in filaggrin
atopic dermatitis
ichthyosis
Malassezia Furfur is the causative agent for which two skin disorders?
Tina versicolor and seborrheic dermatitis
Epidermolysis Bullosa
error in gene encoding the protein type VII collagen
Disease BEST characterized as an acquired one involving antibodies to cell-to-cell adhesion molecules in the stratum spinosum?
Pemphigus vulgaris
First thing that comes to mind:
A. Icthyosis vulgaris – B. Ehlers-Danlos syndrome: C. Vitiligo - D. Pseudoxantoma elasticum – E. Solar elastosis –
A. Icthyosis vulgaris – filaggrin – dry and skin breaks up
B. Ehlers-Danlos syndrome - contortionist (congenital collagen production mutation)
C. Vitiligo - prob with melanocytes
D. Pseudoxantoma elasticum – elastin (chicken skin)
E. Solar elastosis – elastin (old people)
holocrine (whole cell) gland secretion?
holocrine means whole cells Sebaceous glands (think zit thing - sebum)
A patient presents with evidence of palpable purpura and a diagnosis of leukocytoclastic vasculitis is made. Which of the following types of immune reaction types is BEST exemplified by this condition?
Type III—immune complex mediated
immune reaction type that is BEST exemplified by the disease bullous pemphigoid?
Type II—antibody mediated - hemidesmo
immune reaction type that is BEST exemplified by a nickel allergy?
Type IV—delayed type hypersensitivity – allergic contact dermatitis
primarily located where?
- eccrine
- apocrine
- apoeccrine
- eccrine: everywhere, but mostly face, hands, feet
- apocrine: armpit, urogenital
- apoeccrine: armput
___________ glands secrete nearly ten times as much sweat as eccrine glands
• Apoeccrine
___________ glands Sweat is stickier, odorless (initially), then smells upon contact with skin flora, which is different than eccrine glands.
Apocrine
which inflammatory skin diseases are Staphylococcus aureus suggested to play a role in exacerbation of the disorder?
Bullous and non bullous imeptigo
- bullous for sure
strep can cause non bullous as well
Which skin disorder is associated with a history of asthma or hay fever (allergic rhinitis)?
Atopic dermatitis
atopic dermatitis
ichthyosis
both have in common what>?
Filaggrin mutation
A 5-year-old presents with itchy skin and has evidence of rash in the skin creases. His Mom says he’s always had dry skin. He has a history of asthma. Which of the following is MOST associated with his condition?
Filaggrin mutation – atopic dermatitis!!!!
Comorbidities associated with psoriasis?
including arthritis and increased cardiovascular risk.
Bowen’s disease (squamous cell carcinoma in situ) is linked to __________
human papilloma virus (HPV) infection.
Kaposi’s sarcoma is linked to __________
HHV8 virus
Which benign skin tumors is associated with high levels of GLUT-1 expression (a placenta-associated marker)?
. Infantile hemangioma
Sudden appearance of multiple of which of the following benign skin tumors may be associated with adenocarcinoma of the stomach?
Seborrheic keratosis
- remember lesser trelat?
a Tzanck smear detects which viruses?
VZV, HSV
NOT HPV
The appearance of grouped vesicles/pustules on the fingertips is most consistent with ______ infection
HSV
The appearance of vesicles on an erythematous base is associated with _____ or ____ but not _____ infections.
HSV or VZV
not HPV
A 6-year-old boy presents with annular, scaly patch on his arm. KOH prep of skin scraping from the leading edge of the lesion reveal hyphae. Which of the following organisms is the MOST likely etiology of his skin condition?
Trichophyton rubrum - cutaneous
What bacteria causes syphilis?
Treponema pallidum
Ehlers-Danlos syndrome
Ehlers-Danlos syndrome - think contortionist (congenital collagen production mutation)
Melanocytes are located in which layer of the epidermis?
basal layer
What is the thickest layer of the epidermis?
Stratum spinosum
The majority of BCCs have a loss of what fxn?
PTCH (which normally blocks SMO)
- treat with vismodegib
Almost all moles that can lead to malignant melanoma have a mutation in what?
BRAF
-treat with vemurafenib
