Practice exam 2

Question 1

Sturge Weber syndrome

- distribution?

Answer 1

Associated with Port Wine Stain where 10-15% of the capillary malformation is V1 distribution. Thus can casue ocular (glaucoma) and neurologic abnormalities (seizures)

Question 2

What would you use to treat infantile hemangioma?

Answer 2

It has lots of complications remember?

Treat with Beta blockers to decrease angiogenesis

Question 3

Which of benign tumors originates from oil glands?

Answer 3

Sebaceous hyperplasia

*note: Common. Increases frequency after middle age. Could be sunlight induced. Distributes face >trunk> extremities

Question 4

p53

Answer 4

tumor suppressor

Question 5

Skin diseases due to defect in filaggrin

Answer 5

atopic dermatitis

ichthyosis

Question 6

Malassezia Furfur is the causative agent for which two skin disorders?

Answer 6

Tina versicolor and seborrheic dermatitis

Question 7

Epidermolysis Bullosa

Answer 7

error in gene encoding the protein type VII collagen

Question 8

Disease BEST characterized as an acquired one involving antibodies to cell-to-cell adhesion molecules in the stratum spinosum?

Answer 8

Pemphigus vulgaris

Question 9

First thing that comes to mind:

A.  Icthyosis vulgaris –
B.  Ehlers-Danlos syndrome:
C.  Vitiligo  - 
D.  Pseudoxantoma elasticum – 
E.  Solar elastosis –

Answer 9

A. Icthyosis vulgaris – filaggrin – dry and skin breaks up
B. Ehlers-Danlos syndrome - contortionist (congenital collagen production mutation)
C. Vitiligo - prob with melanocytes
D. Pseudoxantoma elasticum – elastin (chicken skin)
E. Solar elastosis – elastin (old people)

Question 10

holocrine (whole cell) gland secretion?

Answer 10

holocrine means whole cells
Sebaceous glands (think zit thing - sebum)

Question 11

A patient presents with evidence of palpable purpura and a diagnosis of leukocytoclastic vasculitis is made. Which of the following types of immune reaction types is BEST exemplified by this condition?

Answer 11

Type III—immune complex mediated

Question 12

immune reaction type that is BEST exemplified by the disease bullous pemphigoid?

Answer 12

Type II—antibody mediated - hemidesmo

Question 13

immune reaction type that is BEST exemplified by a nickel allergy?

Answer 13

Type IV—delayed type hypersensitivity – allergic contact dermatitis

Question 14

primarily located where?

• eccrine
• apocrine
• apoeccrine

Answer 14

• eccrine: everywhere, but mostly face, hands, feet
• apocrine: armpit, urogenital
• apoeccrine: armput

Question 15

___________ glands secrete nearly ten times as much sweat as eccrine glands

Answer 15

• Apoeccrine

Question 16

___________ glands Sweat is stickier, odorless (initially), then smells upon contact with skin flora, which is different than eccrine glands.

Answer 16

Apocrine

Question 17

which inflammatory skin diseases are Staphylococcus aureus suggested to play a role in exacerbation of the disorder?

Answer 17

Bullous and non bullous imeptigo

• bullous for sure
  strep can cause non bullous as well

Question 18

Which skin disorder is associated with a history of asthma or hay fever (allergic rhinitis)?

Answer 18

Atopic dermatitis

Question 19

atopic dermatitis
ichthyosis
both have in common what>?

Answer 19

Filaggrin mutation

Question 20

A 5-year-old presents with itchy skin and has evidence of rash in the skin creases. His Mom says he’s always had dry skin. He has a history of asthma. Which of the following is MOST associated with his condition?

Answer 20

Filaggrin mutation – atopic dermatitis!!!!

Question 21

Comorbidities associated with psoriasis?

Answer 21

including arthritis and increased cardiovascular risk.

Question 22

Bowen’s disease (squamous cell carcinoma in situ) is linked to __________

Answer 22

human papilloma virus (HPV) infection.

Question 23

Kaposi’s sarcoma is linked to __________

Answer 23

HHV8 virus

Question 24

Which benign skin tumors is associated with high levels of GLUT-1 expression (a placenta-associated marker)?

Answer 24

. Infantile hemangioma

Question 25

Sudden appearance of multiple of which of the following benign skin tumors may be associated with adenocarcinoma of the stomach?

Answer 25

Seborrheic keratosis

• remember lesser trelat?

Question 26

a Tzanck smear detects which viruses?

Answer 26

VZV, HSV

NOT HPV

Question 27

The appearance of grouped vesicles/pustules on the fingertips is most consistent with ______ infection

Answer 27

HSV

Question 28

The appearance of vesicles on an erythematous base is associated with _____ or ____ but not _____ infections.

Answer 28

HSV or VZV

not HPV

Question 29

A 6-year-old boy presents with annular, scaly patch on his arm. KOH prep of skin scraping from the leading edge of the lesion reveal hyphae. Which of the following organisms is the MOST likely etiology of his skin condition?

Answer 29

Trichophyton rubrum - cutaneous

Question 30

What bacteria causes syphilis?

Answer 30

Treponema pallidum

Question 31

Ehlers-Danlos syndrome

Answer 31

Ehlers-Danlos syndrome - think contortionist (congenital collagen production mutation)

Question 32

Melanocytes are located in which layer of the epidermis?

Answer 32

basal layer

Question 33

What is the thickest layer of the epidermis?

Answer 33

Stratum spinosum

Question 34

The majority of BCCs have a loss of what fxn?

Answer 34

PTCH (which normally blocks SMO)

• treat with vismodegib

Question 35

Almost all moles that can lead to malignant melanoma have a mutation in what?

Answer 35

BRAF

-treat with vemurafenib