Practice 1

Question 1

What benign neoplasm stains with Glut-1?

Answer 1

Infantile hemangioma

• if mom underwent chronic villi sampling, it could increase risk of these strawberry hemangiomas

Question 2

What mutation is associated with Port wine stain?

Answer 2

GNAQ

does not stain with Glut 1 like infantile hemangioma!

Question 3

How do glucocorticosteroids work?

Answer 3

Inhibition of NF-kappa B

Question 4

What disease causes increased pigmentation?

Answer 4

addisons disease

*darker skin than sister.

Question 5

What is seborrheic dermatitis associated with?

Answer 5

Neuro disorders (parkinsons)
Head trauma
PTSD
HIV

Question 6

When you see “velvet neck” think ___________

- what can cause it?

Answer 6

Acanthosis nigricans

- familial
obesity
endocrinopathies
drugs
cancer ***red flag - rapid weight loss

Question 7

night sweat, red spot on palms (janeway lesions), osler nodes, black streaks in nails (hemorrhagic splinters)

Answer 7

infective endocarditis

Question 8

tightness around mouth, SOB, salt and pepper changes, raynauds

• what disease can it be?
• how can you dx it?

Answer 8

systemic scleroderma

ANA+ in 80-90%

• that poor lady in clinic
• pulm/card involvement

Question 9

itchy rash with ulcers with white lace around in the mouth (mucosa)
- How can you make sure?

Answer 9

lichen planus

Look for the signs “4 Ps of lichen planus”

• puritic
• polygonal
• purple papule

Question 10

What do we have to worry about for lichen planus?

Answer 10

hepatitis C

Question 11

If a pt was suspected of nec fasc –> was treated –> gets worse, what is the disease probably?

Answer 11

pyoderma gangrenosum
(expanding ulcer)

• pathergy: the more you injure it the more it gets worse

Question 12

Pathergy

• what is it
• what disease is associated with it?

Answer 12

The more you injure it, the more it gets worse

• pyoderma gangrenosum

Question 13

Most pts 50-70% of pts with pyoderma gangrenosum have what underlying condition?

Answer 13

inflammatory bowel disease

• 2nd most common is ulcerative colitis or crohns

Question 14

Nails are curled in

- name

Answer 14

koilonychia

Question 15

wood grain on the chest, think ________

Answer 15

lung cancer

Question 16

Shawl sign, think ______

Answer 16

dermatomyositis

Question 17

Which viruses require RdRp?

Answer 17

All (-) strand RNA viruses and double-strand RNA viruses

Question 18

Viral attachment and subsequent entry into cells generally occurs through specific or non-specific interactions with the lipid by-layer??

Answer 18

Specific (otherwise we would be double screwed) think about their glycoproteins!

Question 19

How do interferons respond to viral infxns?

Answer 19

Interferons induce cellular resistance to viral replication

- IFNs (interferes with viral infection of neighboring cells) which induces the anti-viral state.

Question 20

Are Interferons generally directly toxic to viruses?

Answer 20

no

Interferons induce cellular resistance to viral replication
- IFNs (interferes with viral infection of neighboring cells) which induces the anti-viral state.

Question 21

Adverse Drug Reactions of acyclovir

Answer 21

IV → Encephalopathy Renal toxicity w. IV route

Question 22

What do plaque assays measure?

Answer 22

A. Infectivity of a sample

Question 23

acute local disease (ie: common cold)

• incubation period
• virus shedding and transmission
• host responses
• likelihood of re-infection

Answer 23

• incubation period: short
• virus shedding and transmission: many serotypes are rapidly mutating, resulting in short lived immunity
• host responses: secretory IgA
• likelihood of re-infection: common

Question 24

acute systemic disease (ie: measles)

• incubation period
• virus shedding and transmission
• host responses
• likelihood of re-infection

Answer 24

• incubation period: long
• virus shedding and transmission: primary infxn in epithelium but can result in 2nd replication sites
• host responses: secretory IgA and serum IgG
• likelihood of re-infection: low

Question 25

Short-lived immunity (primarily secretory IgA) is associated with acute systemic or acute local disease?

Answer 25

acute local

Question 26

Is it recommended for immunocompromised individuals to receive the influenza vaccine?

Answer 26

influenza vaccine is inactivated so it doesnt matter

unlike the chicken pox VZV one!

Question 27

Varicella-zoster virus (VZV) primary infection is BEST characterized as acute local or acute systemic infxn?

Answer 27

Acute systemic infection

Question 28

Amantadine targets which of the following stages of the life cycle of influenza virus?

Answer 28

Viral uncoating

Question 29

. Acyclovir preferentially targets which of the following enzymes for its antiviral activity?

Answer 29

Viral DNA polymerase

Question 30

Caspofungin does/does not? directly target ergosterol pathways

Answer 30

does not

-

Question 31

Drug BEST for P. jirovici (carinii) pneumonia in AIDS patients.

Answer 31

Pentamidine

Question 32

Dimorphic: fungi

Answer 32

o Some Can Have Both Phases =  (For thermal dimorphic species)
		§ Sporothrix schenkii
		§ Coccidioides immitis
		§ Histoplasmosa capsulatum
		§ Blastomyces dermatitides
		§ Paracoccidiodes brasiliensis

Question 33

. Katayama fever corresponds to which of the following aspects of schistosomiasis?

Answer 33

Worm maturation and laying of eggs