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BL DD final > Antivirals > Flashcards

Antivirals Flashcards

1
Q

Role of pharmacotherapy in treatment with Peramivir

A

Only for critically ill or immunocompromised

  • NA inhibitor for Influenza A and B
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2
Q

Amantadine (Symmetrel) Route of administration

A

Orally with accumulation in lungs

-Rimantadine is also

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3
Q

Rimantadine (Flumadine) Route of administration

A

Orally with accumulation in lungs

  • Amantadine is also
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4
Q

MOA: describe different Kinases involved in TPing for acyclovir, ribavirin, and ganciclovir

A

Acyclovir - TP via viral thymidine kinase

Ribavirin - TP via cellular kinase

Gancyclovir - TP by viral UL97

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5
Q

Oral Acyclovir role of pharmacotherapy in treatment:

A

Oral ↓ symptom duration during primary and
recurrent genital herpes (NOT time to healing).
Need higher doses for varicella or shingles,
but decreases duration.

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6
Q

Topical Acyclovir role of pharmacotherapy in treatment:

A

Topical less effective. Good for 2ndary prevention.

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7
Q

Penciclovir (Denavir)

role of pharmacotherapy in treatment:

A

Rx HSV and VZV

  • famciclovir is as well
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8
Q

Mechanism of action

Ribavirin

A

Converted to ribavirin-TP by cellular kinases.

1) Inhibits 5’ capping of viral mRNA, ↓stability and translatability
2) ↑viral suicide

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9
Q

Adverse Drug Reactions

Ribavirin

A

Hemolytic anemia. When given with interferon, causes cough, rash and pruritus.

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10
Q

role of pharmacotherapy in treatment:

Ribavirin copegus

A

RSV infxn in bone marrow transplant and other immunocompromised, Rx for Hepatitis C when combined with interferon-α2a

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11
Q

role of pharmacotherapy in treatment:

Ribavirin Virazole

A

Rx for RSV and pneumonia in severe RSV and immunocompromised

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12
Q

ROA of Valganciclovir and cidofovir

A

IV for both

to treat CMV

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13
Q

Adverse drug rxns of cidofovir

A

Nephrotoxicity

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14
Q

Role of pharmacotherapy in treatment

Cidofovir

A

good for CMV infxns if resistant to ganciclovir/foscarnet, or HSV if resistant to acyclovir

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15
Q

IV ganciclovir role of pharmacotherapy in treatment

A

Rx of chronic CMV retinitis in immunocompromised patients. Control CMV in transplant patients.

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16
Q

Topical ganciclovir role of pharmacotherapy in treatment

A

Topical treats HSV keratitis.

17
Q

Oral ganciclovir role of pharmacotherapy in treatment

A

Oral has some benefit for HBV

18
Q

MOA of foscarnet

A

Does not require cellular activation. Non-competitively binds RNA and DNA pol to inhibit cleavage of pyrophosphate. Block viral replication

19
Q

ROA of foscarnet

A

IV

to treat CMV

20
Q

Adverse Drug Reactions

of foscarnet

A

Nephrotoxicity (renal impairment) and

Electrolyte imbalance (hypocalcemia).

Some CNS abnormalities, rash, fever, nausea

21
Q

Adverse drug rxns of ganciclovir

A

bone marrow despression/ myelosuppression

BL DD final (18 decks)

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