DD malignant tumors Flashcards
Basal cell carcinoma subtypes
○ Nodular
○ Superficial (can see bleeding)
○ Infiltrative
○ Sclerosing (morpheaform)
Most common pre-malignant skin lesion.
Actinic keratosis
○ Eventually develop into squamous cell carcinoma (1/1000 )
Squamous cell carcinoma (SCC) subtypes
- Squamous cell carcinoma in situ (Bowen’s disease)
- Keratoacanthoma
Melanoma ABCDE
Assymetry Border Color Diameter Evolving
Melanoma subtypes
○ Superficial spreading
○ Nodular
○ Lentigo Maligna Melanoma
○ Acral Lentiginous
Kaposi’s Sarcoma:
- 3 Types:
○ Classic
○ Lymphadenopathic
○ AIDS associated
Smoking is a risk for what type of carcinoma?
• Smoking
○ Risk ONLY for SCC
Melanoma risk factors
• Mutation in the BRAF gene, defective DNA repair
○ This is not inherited ○ Occurs during development of melanoma ○70% of the time arise de novo.
actinic keratoses (AKs) are precursors to ______
squamous cell carcinoma
BCC = patch 1 mutation
• The patch 1 gene is a tumor suppressor gene
○ BCC comes from pluripotent cells due to mutations in the hedgehog pathway
hedgehog pathway unable to signal PTCH1 –> PTCH1 is unable to inactivate SMO (smoothened) –> it goes on to signal tumor growth
Vismodegib
cancer drug that inhibits SMO (smoothened) if PTCH1 is faulty
BRAF mutation
Normal BRAF - normal cell growth
Mutated BRAF - uncontrolled cell proliferation
• Remember… this is UV damage in melanoma
• It is NOT inherited
• Mutation on the B-Raf protein (most common is V600E mutation)
Vemurafenib
inhibits BRAF, causes programmed cell death in melanoma lines → MEK signaling → ↓ cell survival & proliferation
Breslow depth
- Maximal thickness of tumor invasion measured by an ocular micrometer
- Measured from top of granular layer of epidermis to the base of neoplasm
- MOST IMPORTANT prognostic factor for melanoma
Clark Level:
- How far melanoma has penetrated into the skin without measuring it
- Higher number (5)= deeper
1: confined to epidermis
2. invasion of papillary dermis
3. filling of papillary dermis but not extending to reticular dermis
4. invasion of reticular dermis
5. invasion of the deep, subcutaneous tissue