Powerpoint 3 Flashcards
What are examples of Adverse effects of neurotoxicity?
- any undesired affect (discomfort, disorientation)
- Any alteration that reduces the ability of an organism to survive, reproduce, or adapt to its environment
- Permanent or reversible
- produced by neuropharmacological or neuro-degenerative properties of a neurotoxicant, or the result of indirect actions on the nervous system
Neurotoxicity is (complex/simple) and (unilayered/multilayered)
Complex, multilayered
True or false:
The nervous system has a large functional reserve and may not be observable as a functional change until the damage is extensive
True
What is eipgenetics?
The turning on and off of genes
What does a neurologist do?
Diagnose and treat diseases of the nervous system
There are more than ______chemicals which are known to be neurotoxicity in laboratory studies, but approx. _____ are proven to be neurotoxic to humans.
1000, 200
What must neurons be before they can do their function?
Mature
What causes neurons to not differentiate, mature, or reach its destination?
Neurotoxins
True or False:
Placental dysfunction provides one of the bio markers of exposure to toxicants
True
Are there higher opportunities for prevention of toxic events in prenatal or postnatal babies?
Prenatal
True or False:
Neurotoxicity causes impaired CNS function that lasts a lifetime
True
what three processes done by cells is involved in formation of brain structures?
cell proliferation, migration, and differentiation
Why does failure in cell proliferation or cell migration to the proper location occur?
because of toxic insults having deleterious effects on the developing brain
Fetal basis of adult neural disease hypothesis: Damage at ____ early stage affects what?
Any; Dependent ensuing structural development
What induces brain dysfunctions AND neurodevelopmental disorders?
Alterations in Cell signaling pathways
