Powerpoint 10 (slides 1-11)

Question 1

What two main organs does Lead (Pb) affect?

Answer 1

The kidneys and brain

Question 2

What 4 effects does lead poisoning have on a child’s development?

Answer 2

1. Damage to the brain and nervous system
2. Slowed growth and development
3. Learning and behavior problems
4. Hearing and speech problems

Question 3

The effects of lead poisoning can lead to what three things?

Answer 3

1. Lower IQ
2. Decreased ability to pay attention
3. Underperformance at school

Question 4

Prenatal exposure to Lead allows Lead to cross the ________.

Answer 4

Placenta

Question 5

What is one of the most known developmental disorders for a child (not the most common)?

Answer 5

ADHD

Question 6

Children’s developing brains and other organ systems are very __________ to Pb

Answer 6

Sensitive

Question 7

What is one of the most important protection mechanisms in the Central Nervous System?

Answer 7

The Blood Brain Barrier

Question 8

What type of glial cell gives support and guidance during neuronal transport?

Answer 8

Astrocytes

Question 9

Which glial cells surround the BBB?

Answer 9

Endothelial cells and Astrocytes

Question 10

True or False:

The cellular effects of lead ions diffusing across the BBB is related to what happens in the brain?

Answer 10

FALSE

It has NOTHING to do with the brain. It affects hormones

Question 11

What does lead disrupt as a neurological effect of lead ions diffusing across the blood brain barrier?

Answer 11

Communication between Astrocytes and endothelial cells