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MSDF > Power Conversion in Mitochondria II > Flashcards

Power Conversion in Mitochondria II Flashcards

1
Q

What is complex II also known as?

A

Succinate Dehydrogenase

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2
Q

How many protein make up complex II?

A

4

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3
Q

What cofactors does complex II contain?

A
  • FAD
  • 3FeS centres
  • b-type heme
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4
Q

What is reduced as succinate is oxidised in complex II?

A

FAD

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5
Q

How are the proteins arranged in complex II?

A
  • 2 proteins in matrix
  • 2 proteins in membrane
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6
Q

What happens in Complex II?

A
  • FAD reduced and succinate oxidised
  • electron moves up FeS centres to heme and used to reduce quinone pool
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7
Q

Are protons pumped in complex II?

A

No as protons are taken from the matrix side

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8
Q

What is complex III also known as?

A

bc1 complex

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9
Q

What is the structure of complex III?

A
  • Dimer of 11 different subunits
  • Each monomer has 3 core subunits
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10
Q

What are the 3 core subunits of complex III monomers?

A
  • Rieske (FeS) protein
  • Cytochrome b
  • Cytochrome c1
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11
Q

What mechanism is used to pump H+ by complex III?

A

Direct mechanism

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12
Q

What happens in complex III?

A
  • Modified Q cycle
  • Reduction of cytochrome c, oxidation of ubiquinol to ubiquinone
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13
Q

How many Cyt c1 are reduced by 1 electron in complex III?

A

2

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14
Q

How many H+ does the Q cycle transport in 1 ‘turn’?

A

4

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15
Q

What does cytochrome c do?

A

Picks up electrons from complex III and delivers to complex IV

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16
Q

What is complex IV also known as?

A

Cytochrome c oxidase

17
Q

What cofactors does complex III contain?

A
  • FeS in Rieske protein
  • Heme from cytochromes
18
Q

What redox does Complex IV contain?

A
  • CuA
  • CuB
  • Haem a
  • Haem a3
19
Q

How are the Cu atoms in CA of complex IV arranged?

A

2Cu atoms are co-ordinated by Cys and His sidechains

20
Q

What is the structure of complex IV?

A

Dimer of 13 different subunits

21
Q

Which subunits of complex IV contain redox centres?

A

Subunit I and II

22
Q

How many electrons are moved per O2 in complex IV?

A

4 electrons

23
Q

How many H+ are moved per 4 electrons in complex IV?

A

4

24
Q

Passing 2 electrons from NADH to 1/2 O2 results in how many H+ being pumped?

A

10 H+

25
Q

Passing 2 electrons from succinate to 1/2 O2 results in how many H+ being pumped?

A

6H+

MSDF (30 decks)

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