Potassium Sparing Diuretics Flashcards
1
Q
What is the MOA of spironolactone?
A
Aldosterone antagonist in the collecting duct, so blocks the sodium reabsorption and potassium secretion.
2
Q
What is the MOA for Amiloride and Triamterene?
A
Block luminal sodium channels in the collecting ducts.
3
Q
What are the 2 things increased in the urine from potassium sparing diuretics and 1 thing decreased?
A
- Na and Water
2. Potassium
4
Q
What is the use for amiloride and triamterene?
A
Used in conjunction with other diuretics to spare the potassium
5
Q
What are the three major clinical uses of Spironolactone?
A
Hypertension, heart failure, and hyperaldosteronism
6
Q
What are the two adverse effects of spironolactone?
A
Hyperkalemia and endocrine effects
