Loop Diuertics

Question 1

What is the MOA of loop diuretics?

Answer 1

Inhibit the Na/K/2Cl co transporter in the thick ascending loop of henle

Question 2

What 4 things are increased in the urine due to Loop Diuretics?

Answer 2

NaCl, Potassium, Calcium and Water

Question 3

2 very important notes to consider about the effectiveness of loop diuretics working regardless of the state of the patient?

Answer 3

1. They work regardless of the patient having concentrated or diluted urine to begin with
2. They work with low RBF and GFR.

Question 4

What are the two main therapeutic uses for Loop Diuretics?

Answer 4

1. Acute pulmonary edema

2. Acute/chronic peripheral edema due to heart failure or kidney failure.

Question 5

What is the one unique adverse effect of using a loop diuretic and what is the drug that causes it?

Answer 5

Ototoxicity. Ethacrynic acid