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DDS Final > Polymers > Flashcards

Polymers Flashcards

1
Q

Polymer

A

many parts
Large molecule made up of many small repeating units
Also called macromolecules (not always repeating units)

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2
Q

Monomer

A

small molecule that combines with the same type of molecule or different types to form a polymer

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3
Q

Polymer structure

A

Long
Repeating
Dimer, trimer, tetramer, and pentamers

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4
Q

Polymers are classified based on

A

Origin (natural or synthetic)
Biostability (biodegradable)
Reaction (addition or condensation)
Arrangement of monomers

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5
Q

Natural vs synthetic polymers

A

N: proteins, carbs, DNA, RNA
S: polyester, polyamides

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6
Q

Biodegradable polymers

A

Made of monomers that are linked to each other via unstable function groups

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7
Q

Non-biodegradable polymers

A

Excreted in intact form or stay in the body for a long time

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8
Q

Homopolymers

A

Formed by identical monomeric units

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9
Q

Copolymers

A

Formed from more than one monomer type

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10
Q

Block or graft copolymers

A

Various arrangements of the monomers in teh copolymer molecules

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11
Q

Properties of polymers

A

Chemical reactivity depends on chemistry of the monomers

Depend on way the monomers are put together

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12
Q

Monodispersed Polymers

A

Polymer sample have the same molecular weight
All molecules will have the same chain length
Proteins, DNA

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13
Q

Polydispersed

A

Polymer sample has molecules of different chain lengths with a range of weight
Synthetic polymers

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14
Q

Gel properties

A

Cross-linked systems

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15
Q

Type 1 Gel

A

Irreversible systems with 3D network formed by covalent bonds

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16
Q

Type II Gels

A

Heat-reversible; head together by hydrogen bonds

17
Q

Gel Point

A

Temperature at which a polymer solution starts to form gel

18
Q

Implants

A

Inserted in the dehydrated state and let the polymer swell to fill a body vacity or to give a form to the surrounding tissue
Vehicles for antibodies and surgical sutures

19
Q

Bio-responsive drug delivery systems

A

Swelling properties of a polymer gel can be changed by heat, pH or application of electrical current to develop

20
Q

Carbomer or Carbopol

A

Suspending agents

21
Q

Celluloes derivatives

A

Prolongs the action of medicated eye drops and is employed as artificial tears

22
Q

Dextran

A

Plasma expander –> maintain blood volume

Wound-dressing

23
Q

Edema

A

Ion-exchange resins

24
Q

Pholtex

A

Prolongation of drug action

25
Q

Lipid lowering agents: Bile acid sequestrants

A

Cholestyramine, colestipol, colesevelam

26
Q

Drug formulations

A

Film coatings
Matrices
Rate-limiting membranes and devices

DDS Final (8 decks)

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