Physical Pharmacy

Question 1

Physical pharmacy

Answer 1

Quantitative and theoretical aspects

Question 2

Three fundamental dimensions

Answer 2

Length
Mass
Time

Question 3

Force

Answer 3

Directly proportional to the mass when acceleration is constant and vice versa
f= m*a
Dynes

Question 4

Pressure

Answer 4

Force per unite area
dyne/cm^2 = atm = mercury
density * gravity * height = pressure

Question 5

Energy

Answer 5

Property of a bdoy that gives it the capacity to work
1 erg = 1 dyne * 1 cm
1 joule = 1*10^7 erg

Question 6

Thermal energy

Answer 6

Amount of heat necessary to raise the temperature of 1 gram of water from 15 to 15 celsius
Calorie = 4.184 joules

Question 7

Intermolecular forces

Answer 7

Forces that keep molecules in aggregates in gases, liquids and solids

Question 8

Repulsive forces

Answer 8

Molecules are brought close enough together that the outer charge clouds of the molecules touch

Question 9

Attractive forcues

Answer 9

Bring molecules together
Cohesion: like molecules
Adhesion: unlike molecule

Question 10

Van der Waals Forces types

Answer 10

Keesom (dipole-dipole)
Debey (dipole-induced dipole)
London (induced dipole-induced dipole)

Question 11

States of matter

Answer 11

Gases
Liquids
Crystalline solids

Question 12

Sublimation

Answer 12

Solids with high vapor pressure may pass directly from the solid to the gaseous state

Question 13

Deposition

Answer 13

Recondensation to the solid state

Question 14

Mesophase

Answer 14

Between liquid and crystalline states

Question 15

Gaseous state

Answer 15

Vigorous randome motion and frequently collide

Question 16

Critical temperature

Answer 16

Very high temperature, a gas cannot be liquefied regardless the pressure applied and the temperature above which a gas cannot exist in liquid state

Question 17

Critical Pressure

Answer 17

Pressure required to liquefy a gas at its critical temperature

Question 18

Aerosols

Answer 18

Drug is dissolved in a propellant (liquid under pressure but gas in air)

Question 19

Polymorphism

Answer 19

Exist in more than one crystalline form

Contain solvents: solvates or pseudopolymorphs

Question 20

Enatiotropic

Answer 20

When the change from one form to another ir reversible

Question 21

Monotropic

Answer 21

When change from one to another is one directional

Question 22

Amorphous solids: Supercooled liquids

Answer 22

Molecules in amorphous solid are arranged in a random manner
Do not have a definite melting point
Isotropic (similar properties at different directions)
Anisotropic (different characteristics in different directions)