PnT 6

Question 1

Give all the details of the muscarinic effects across the body(4)

Question 2

Explain how anticholinesterase can have effects on the CNS in patients(1)

Question 3

Describe the mechanism of action of Irreversible Anticholinesterase Drugs, what type of compounds are these drugs, how are they removed. List example of these drugs and identify the ones that are currently in clinical use(1)

Question 4

• Give an example of how Ecothiopate is administered for it’s use. Describe the side effects of this drug.(1)

Question 5

What are cholinomimetics(10s)

Question 6

Recall the distribution of muscarinic and nicotinic receptors in the autonomic nervous system(1)

Question 7

What are the two main types of cholinomimetics(2s)

Question 8

Differentiate between muscarine and atropine, and what are muscarinic effects(1)

Question 9

Describe what Directly Acting Cholinomimetic Drugs are, describe the structure and features of the two types of cholinomimetic drug, explain what they are used for and explain their side effects(3)

Question 10

Describe and explain the treatement for organophosphate poisoning(1)

Question 11

Explain the mechanism of action of anticholinesterase drugs, name two types of (1)

Question 12

Explain what the cause of glaucoma is and why stimulation of the muscarinic receptors is useful for glaucoma.(1)

Question 13

Describe the distribution of muscarinic receptors and the mechanism for their mode of action.(2)

Question 14

Describe the three main muscarinic effects on the eye(30s)

Question 15

Describe the function of Indirectly Acting Cholinomimetic Drugs in general(1)

Question 16

What is the general function of cholinesterase enzymes, differentiate between the distribution, substrate specificity and function of two types of cholinesterase enzymes(2)

Question 17

Describe the effects of cholinesterase inhibitors at different doses(1)

Question 18

Describe the Synthesis, Release and Metabolism of Acetylcholine(1)

Question 19

What are nicotinic receptors, describe the structure of nicotinic recptors, what determines the binding properties of receptors and compare the strength of the effects in the two types of nicotinic receptors.(1)

Question 20

For the Reversible Anticholinesterase Drug, physostigmine, name:(1)