Pharmacology and therapeutics 2

Question 1

Give the details of the different types of drug antagonism

Answer 1

pg 1(4)

Question 2

Tolerance to the euphoric effects of drugs of abuse (e.g. heroin & cocaine) can occur after repeated use. Which form of tolerance would not involve any. change in the cells that mediate the euphoric effects?

A: Receptor desensitisation

B: Receptor down-regulation

C: Exhaustion of mediator stores

D: Receptor up-regulation

E: Increased metabolic degradation

Answer 2

pg 4

Question 3

What is drug tolerance , describe what the different causes of drug tolerance are

Answer 3

pg 1(4)

Question 4

Give the details of the different receptor families, describing spee and mechanism, compodtion and/or with examples

Answer 4

pg 2(8)

Question 5

A 4 year old girl is bitten by a tiger snake whilst holidaying in Australia. An anti-venom( harvested antibodies) is administered. Which form of antagonism is utilised by the anti-venom?

A: Competitive receptor blockade

B: Physiological anatagonism

C: Chemical antagonism

D:Pharmacokinetic antagonism

E:Irreversible receptor blockade

Answer 5

pg 4

Question 6

Explain the concept of use dependency and how local anaethetics work as a result

Answer 6

pg 1