Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > PNS pharmacology > Flashcards

PNS pharmacology Flashcards

1
Q

Drug inhibiting step 2 (storage): Ach stored in VAT

A

Vesamicol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Rate-limiting step in Cholinergic pathway

A

Conversion of Acetyl-Coa and Choline to Ach by ChAT

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Drug altering synaptobrevins (SNARE proteins triggered by Ca) to prevent release of ACh (Step 3)

A

Botulinum toxins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

3 drugs inhibiting degradation of Ach to choline & acetate by acetylcholinesterase (Step 4/ termination)

A

Carbamates
Organophosphates
Neostigmine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Types of NS that causes erection and ejaculation

A

Erection: PNS; Ejaculation: SNS

Point & Shoot

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Parasympathetic NS have _______ PREganglionic fibers & ______ POSTganglionic fibers.

A

Long; Short

PLaSma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Gq-coupled cholinergic receptor (inc in IP3 & DAG) in nerve endings

A

M1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Gi-coupled cholinoreceptor found in heart and some nerve endings (dec cAMP)

A

M2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Gq-coupled cholinoreceptor which relaxes bronchial smooth muscles and increase GI secretion

A

M3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Blocks step 1 (synthesis) of Ach from acetyl-CoA + choline

A

Hemicholinium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Direct-acting cholinomimetic (M1-3) used for bladder and bowel atony post-op

A

Betanechol

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Direct-acting cholinomimetic (M3 in ciliary m & salivary g) used in glaucoma, sjogren & sicca syndrome

A

Pilocarpine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Autoimmune disorder characterized by xerostomia, xerophthalmia, rheumatoid arthritis

A

Sjogren syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Direct-acting cholinomimetic (Nn, Nm) used for smoking cessation

A

Nicotine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Indirect-acting cholinomimetic MOA

A

Binds to cholinesterase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Indirect-acting cholinomimetic used in tensilon test for myasthenia gravis; very short-acting (5-15 mins)

A

Endrophonium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Indirect-acting cholinomimetic with muscarinic effects blocked by atropine & pralidoxime

A

Neostigmine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Autoimmune destruction of nicotinic Ach receptors characterized by fluctuating muscle weakness and ocular symptoms (ptosis, lagophthalmos)

A

Myasthenia gravis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Acute worsening of MG symptoms due to infx, stress or undermedication

A

Myasthenic crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Excessive activation of cholinoreceptors due to overmedication (skeletal m weakness and ParaSy signs)

A

Cholinergic crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Endrophonium ______ muscle strength in cholinergic crisis.

A

weakens

improves in myasthenic crisis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Indirect-acting cholinomimetic used for Alzheimer’s disease

A

Rivastigmine
Donepezil
Galantamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

What type of poisoning presents with the ff sx:

Diarrhea, urination, miosis, bronchospasm, bradycardia, excitation (CNs, skeletal m), lacrimation, sweating, salivation

A

Organophosphate poisoning

DUMBBELSS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Cholinergic antagonist blocking all M receptors, 1st choice in organophosphate poisoning; used as mydriatic and cyclopegic

A

Atropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Cholinesterase regenerator; binds phosphorus of organophosphate; used in nerve gas poisoning

A

Pralidoxime

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

Cholinergic antagonist (all M) reducing tremors more than rigidity in Parkinson’s

A

Benztropine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Cholinergic antagonist (M3) used in asthma and COPD; more effective and less toxic for COPD patients with heart dse

A

Ipratropium

28
Q

Muscarinic antagonist for Parkinsonism

Try to Park your Benz, beep here

A

TRIhexyphenidyl
BENZtropine
BIPeriden

29
Q

Transdermal cholinergic antagonist used in motion sickness

A

Scopolamine

30
Q

CI to muscarinic blockers

A

Caution in infants (bad thermoregulation)
Acute angle closure glaucoma
BPH

31
Q

Cholinergic nicotinic antgagonist (ganglion blocker)used in hypertensive emergencies; SE: postural hypotension

A

Hexamethonium

32
Q

Depolarizing neuromuscular blocker

Kapag nakapag-DEPOsit ka sa toilet, SUCCess yun.

A

Succinylcholine

DEPOlarizing = SUCCinylcholine

33
Q

Nondepolarizing NMB; causes flaccid paralysis

-CURe

A

Pancuronium
Tubocurarine
Atracurium
Vecuronium

34
Q

Primary transmitter at SY postganglionic synapses

except in eccrine sweat glands and vasodilator SY fibers in skeletal m

A

Norepinephrine

35
Q

Symphatomimetic used for shock d/t renal shutdown

A

Dopamine

Dopamine DILATES renal vessels, NE CONSTRICTS

36
Q

Prevents synthesis in noradrenergic pathway

A

Metyrosine

prevents tyrosine to be converted to DOPA

37
Q

Inhibits vesicular transport and storage in noradrenergic pathway

A

Reserpine

38
Q

Inhibits release of NE in noradrenergic pathway

A

Guanethidine

39
Q

Inhibits excess NE reuptake in synaptic terminals

A

Cocaine

TCAs

40
Q

Inhibits metabolism of NE to metabephrine and VMA

A

MAOIs

COMT inhibitors

41
Q

Alpha-1 adrenergic effects

A

Inc vascular resistance
Mydriasis
Erects hair
Glycongenolysis in liver

42
Q

Alpha-2 adrenergic effects

A

Contracts some vascular SM (inc resistance)
Inhibit NT release
Platelet aggregation
Inhibits lipolysis and insulin release

43
Q

Beta-1 adrenergic effects

A

Inc HR

Inc renin release

44
Q

Beta-2 adrenergic effects

A

Relax airways
Inc insulin release, glycogenolysis
Tremor
Inc HR

45
Q

Drug of choice for anaphylaxis; sympathomimetic, nonselective direct-acting

A

Epinephrine

46
Q

Nonselective sympathomimetic used as last resort for cardiogenic and neurogenic shock; causes reflex bradycardia, extreme vasospasm, tissue necrosis

A

Norepinephrine

47
Q

Low dose dopamine acts on ____ receptors on splanchnic and renal beds

A

D1

48
Q

Medium dose dopamine acts on ___ receptors inc renal BF, HR and CO

A

Beta-1

49
Q

High dose dopamine acts on ___ receptors causing vasoconstriction and inc BP

A

alpha

50
Q

Alpha-1 selective agonist causing rhinitis medicamentosa; cause mydriasis without cycloplegia

A

Phenylephrine

51
Q

Selective alpha-2 agonist used for HPN urgency and opioid withdrawal; causes rebound HPN

A

Clonidine (Catapres)

-max dose: 900 mcg (16 tabs)

52
Q

Alpha-2 selective agonist used in preeclampsia, gestational HPN; can cause hemolytic anemia

A

Methyldopa

53
Q

Selective alpha-2 agonist for glaucoma

A

Apraclonidine

54
Q

Selective beta-1 used for cardiogenic shock; used in cardiac stress testing; prone to tachyphylaxis

A

Dobutamine

55
Q

Beta-2 selective agonists; DOC for acute asthma attacks

A

Salbutamol/ albuterol
Terbutaline
Ritodrine

56
Q

Nonselective alpha blocker (irreversible) used in pheochromocytoma pre-op

A

Phenoxybenzamine

57
Q

Nonselective alpha blocker (reversible) used for rebound hypertension

A

Phentolamine

58
Q

Alpha-1 blocker most selective for prostatic smooth m (BPH)

A

Tamsulosin

59
Q

Alpha-1 blocker for BPH, HPN; SE: 1st dose orthostatic hypotension

A

Prazosin

60
Q

Nonselective beta blocker used as angina prophylaxis, hyperthyroidism, HPN; SE: bronchospasm, erectile dysfx

A

Propanolol

61
Q

2 Beta-blockers without local anesthetic activity for glaucoma

A

Timolol

Betaxolol

62
Q

Betablocker with the longest T1/2

A

Nadolol

NAsa DOLO

63
Q

Beta-blockers with intrinsic symphatomimetic activity

ISA PAng chickenjoy!

A

Pindolol and Acebutolol

64
Q

Betablocker with the shortest T1/2

A

Esmolol

ESMOL=small

65
Q

Only B1 blocker used for SVT

A

Esmolol

same class: atenolol, metoprolol, acebutolol, betaxulol

66
Q

DOC for glaucoma

A

Latanoprost (prostaglandin -inc outflow thru canal of Schlemm)

Pharmacology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions