Anti-arrhythmics

Question 1

Singh-Vaughan Williams Classification

CLASS 2

Answer 1

Beta-adrenoreceptor blockers

Question 2

Singh-Vaughan Williams Classification

CLASS 3

Answer 2

K-channel blockers

Question 3

Singh-Vaughan Williams Classification

CLASS 4

Answer 3

CCB

Question 4

Effects of Class I antiarrhythmics on AP duration

Answer 4

Class IA: prolongs
Class IB: shortens
Class IC: no effect

Question 5

Class IA drugs ideal to use after MI; Duration: 2-3 hrs; used as drip

Answer 5

Procainamide

Question 6

Class IA with marked antimuscarinic effects as SE

Answer 6

Disopyramide

Question 7

Class IA with cinchonism (h/a, vertigo, tinnitus) as SE; also used for malaria; reduces clearance of digoxin

Answer 7

Quinidine

Question 8

Drug to reverse drug-induced arrhythmias

Answer 8

Dobutamine

Question 9

Class IA antiarrhythmics

PioQuiD

Answer 9

Procainamide
Quinidine
Disopyramide

Question 10

Class IB antiarrhythmics

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Answer 10

Mexiletine, Tocainide, Lidocaine

Question 11

DOC for ventricular arrhythmias

Least cardiotoxic among conventional anti-arrhythmics

Answer 11

Lidocaine

Question 12

Drugs that causes agranulocytosis

Answer 12

(CCCAPPIT!)
Clozapine
Cotrimoxazole
Colchicine
Aminopyrine
Phenylbutazone
PTU
Indomethacin
Tocainide

Question 13

Anti-arrhythmic class with no effect on AP duration; Powerful depressants of Na current; used in refractory arrhythmias; CI: post-MI

Answer 13

Class IC

Question 14

Class IC antiarrhythmics

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Answer 14

Propafenone, Flecainide, Encainide

Question 15

Class for beta-adrenoreceptor blockade and reduction in cAMP; AV node sensitive; acts on phase 4; prolongs PR int

Answer 15

Class II anti-arrhythmics

Question 16

Class II; Post-MI prophylaxis; used for thyrotoxicosis

Answer 16

Propanolol, Metoprolol, Timolol

Betablockers

Question 17

Betablocker with Class III properties

Answer 17

Sotalol

Question 18

Class II with selective Beta-1 blockade; used for SVT

Answer 18

Esmolol

Question 19

Beta-1 selective blockers

BEAAM

Answer 19

Betaxolol, Esmolol, Atenelol, Acebutolol, Metoprolol

Question 20

Class of anti-arrhythmics most notorious in causing torsades; prolongs QT interval

Answer 20

Class III

Question 21

Class III used for both tx and prophylaxis of atrial fibrillation

Answer 21

Dofetilide

Question 22

Class III used for SVT and A fib

Answer 22

Sotalol

Question 23

Most efficacious of all anti-arrhythmias; may cause thyroid dysfx

Answer 23

Amiodarone

Question 24

What drug toxicity involves pulmonary fibrosis, paresthesias, tremors, thyroid dysfx, corneal and skin deposits

Answer 24

Amiodarone

Question 25

Class III antiarrhythmics

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Answer 25

Amiodarone
Ibutilide
Dofetilide
Sotalol

Question 26

Class effective in arrhythmias that must traverse Ca-dependent cardiac tissue; prolongs PR interval

Answer 26

Class IV

Dihydropiridine CCBs only

Question 27

Class III used as DOC for SVT maintenance

Answer 27

Verapamil

Question 28

Class IV useful for vasospasm and Raynaud’s phenomenon

Answer 28

Diltiazem

Question 29

Misc antiarrhythmic; DOC for ‘E’ SVT

T1/2: 15s (given intracardiac or with NSS push)

Answer 29

Adenosine

Question 30

Singh-Vaughan Williams Classification

CLASS 1

Answer 30

Na channel blockers