Antibiotics

Question 1

Cell wall synthesis inhibitors, nucleic acid synthesis inhibitors
(Very Finely Proficient at Murder)

Answer 1

BacteriCIDAL
Vancomycin
Fluoroquinolones
Penicillins
Aminoglycosides
Metronidazole

Question 2

MOA of Betalactams

Answer 2

Binds to PBPs, inhibits transpeptidation rxn

Question 3

What contributes to penicillin resistance?

Answer 3

Enzymatic hydrolysis of beta-lactam ring by beta-lactamases
Structural change in target PBPs (MRSA, pneumococci)
Changes in porin structures (Pseudomonas)

Question 4

Natural penicillin given per IV

Answer 4

Pen G

Question 5

Natural penicillin given PO

Answer 5

Pen V

Question 6

The only beta-lactamase resistant penicillin, used in staphyloccocal infx

Answer 6

Isoxazoyl penicilllin:
Methicillin
OXAcillin
ClOXAcillin

Question 7

Aminopenicillin (Extended spectrum to gram -) given parenterally

Answer 7

Ampicillin

Question 8

Aminopenicillin given PO with synergistic effect with aminoglycosides

Answer 8

Amoxicillin

Question 9

Penicillin used for infx caused by Pseudomonas, Enterobacter and Klebsiella
(Takes Care of Pseudomonas)

Answer 9

Piperacilllin
Ticarcillin
Carbenicillin

Question 10

Generation of cephalosporins used for surgical prophylaxis; increases nephrotoxicity of aminoglycosides; more active in gram +
(All CEPH except for 2)

Answer 10

1st gen:
CEPHalexin
CEPHalothin
CEPHapirin
CEPHradine
Cefazolin
Cefadroxil

Question 11

Etiologic agent of pneumonia with currant jelly sputum

Answer 11

Klebsiella pneumoniae

Question 12

All antimetabolites and CHON synthesis inhibitors except aminoglycosides & streptogrammins
(We’re ECSTaTiC about bacteriostatics)

Answer 12

BacterioSTATIC
Erythromycin
Clindamycin
Sulfamethoxazole
Trimethroprim
Tetracycline
Chlorampenicol