Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pharmacology > Endocrine pharmacology > Flashcards

Endocrine pharmacology Flashcards

1
Q

Somatostatin analog used in acromegaly, gigantism and variceal bleeding

A

Octreotide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Role of FSH in men

A

Spermatogenesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Role of LH in men

A

androgen production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

First step in ovulation induction

A

GnRH agonist/antagonist (endogenous means)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Serious complication of ovulation induction

A

ovarian hyperstimulation syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

FSH analog for infertility

A

Follitropin alfa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

LH analog for ovulation induction; from Chinese hamster’s ovaries

A

Choriogonadotropin alfa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

GnRH analog that must be given with Flutamide; causes flare-up of prostate ca

A

Leuprolide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

GnRH antagonist

A

Ganirelix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Dopamine agonist used in hyperprolactinemia and Parkinson’s Disease

A

Bromocriptine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Side effects of Bromocriptine

A

Erythromelalgia

Raynaud’s phenomenon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Fetal complication of high-dose oxytocin

A

Failure of descent d/t sustained contraction
Fetal distress
Placental abruption

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

ADH agonist used in Central DI, vW disease, variceal bleeding

A

Desmopressin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

ADH antagonist for SIADH

A

Conivaptan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

ADH antagonists more specific for V2 receptors

A

Tolvaptan

Lixivaptan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Side effect of conivaptan

A

Hyperkalemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

4 steps in synthesis and transport of thyroid hormones

A

Transport
Iodine organification
Coupling
Proteolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Biologically active thyroid hormone

A

T3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

T3 is ____x more potent than T4

A

10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Autoimmune d/o where B lymphocytes produce an Ab that activates TSH receptor causing thyrotoxicosis

A

Graves disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Endpoint of MOA of thyroid hormones

A

RNA formation and CHON synthesis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Thyroid hormone that must be lowered in pts w/ longstanding hypothyroidism

A

Levothyroxine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Onset of action of PTU

A

3-4 weeks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

MOA of PTU

A

Inhibits conversion of T4 to T3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
SE of PTU
Agranulocytosis
26
MOA of methimazole
Blocks iodine organification
27
SE of methimazole
Phantom taste and smell Agranulocytosis Cholestatic jaundice
28
Tx for agranulocytosis
Recombinant G-CSF
29
Treatment causing permanent hypothyroidism
Radioactive iodine (I 131)
30
Drug that is associated with escape phenomenon in 2-8 weeks; reduces vascularity and size of thyroid gland
Potassium iodide
31
MOA of potassium iodide
inhibit iodide organification
32
Antithyroid drugs that inhibit peripheral conversion of T4 to T3
PTU Propanolol Hydrocortisone
33
Ingestion of iodine causes hypothyroidism
Wolf-Chaikoff effect
34
Ingestion of iodine causes hyperthyroidism
Jod-Basedow phenomenon
35
Regulate Na and K reabsorption in the CT of kidney
Mineralocorticoids
36
Highest salt-retaining mineralocorticoid
Fludrocortisone
37
Prototype of cortisol
Hydrocortisone
38
Uses of hydrocortisone
Acute adrenal insufficiency Status asthmaticus Thyroid storm
39
SE of Prednisone
``` Adrenal suppression Behavioral changes - Steroid rage (common in body builders) Osteoporosis Salt retention Glucose intolerance ```
40
Drug used for Addison's disease and postural orthostatic tachycardia
Fludrocortisone
41
Drug for adrenal-replacement therapy post adrenalectomy
Fludrocortisone
42
Causes of iatrogenic Cushing's syndrome
exogenous steroid intake
43
Causes of adrenal Cushing's syndrome
Cortisol-secreting adrenal adenoma
44
Causes of pituitary Cushing's syndrome
ACTH-secreting adrenal adenoma
45
Causes of ectopic Cushing's syndrome
paraneoplastic ACTH production (from lung tumors)
46
Drug of choice for pregnant patients with Cushing's; used in dx testing for pituitary problem or tumors
Metyrapone
47
MOA of aminoglutethimide
Inhibits desmolase
48
MOA of ketoconazole
Inhibits cholesterol sidechain cleavage
49
Ethinyl estradiol increases the risk of ___ cancer
endometrial
50
Causes clear cell vaginal adenoCA and testicular CA
Diethylstilbestrol
51
Progestin drug that is an appetite stimulant
Megestrol
52
Progestin used in combination with ethinyl estradiol
Norgestrel
53
Most common SE of OCPs
Breakthrough bleeding
54
Progestin-only IM prep
Medroxyprogesterone acetate (Depo-Provera)
55
Combined oral contraceptive
Estradiol + Norethindrone
56
Postcoital contraceptive used for emergency contraception
Levonorgestrel
57
SERM that decreases contralateral spread of breast CA, prevents osteoporosis but increases endometrial Ca risk
Tamoxifen
58
SERM with no estrogenic effects in endometrial tissue
Raloxifene
59
SERM associated with multiple pregnancies
Clomiphene
60
Estrogen synthesis inhibitor; for Tamoxifen-resistant breast Ca
Anastrozole
61
Ovarian inhibitor used in endometriosis; CI in pregnant patients d/t masculinization of female fetus
Danazol
62
Glucocorticoid/ progesterone receptor antagonist used in medical abortion
Mifepristone (RU-486)
63
Anabolic steroid used in performance enhancement in athletes
Oxandrolone
64
Androgen antagonist used in prostate CA
Flutamide
65
Androgen used in male hypogonadism and precocious puberty in males
Testosterone
66
Androgen antagonist w/ orphan drug status used for hirsutism
Cyproterone
67
5-a reductase inhibitor used in BPH
Finasteride
68
Lab test used to differentiate Type 1 and 2 DM
C-peptide
69
Rapid-acting insulin
Lispro Aspart Glulisine
70
Whipple's triad for dx insulinoma
Hypoglycemia after fasting/heavy exercise Low plasma glucose Glucose relieves symptoms
71
Short-acting insulin
Regular
72
Intermediate-acting insulin
NPH | lente
73
Long-acting insulin
Ultralente
74
Ultra-long insulin
Glargine Lantus Detemir
75
Early morning hyperglycemia effects
Somogyi effect Waning of Insulin dose Dawn phenomenon
76
Hypoglycemia at 3am | Hyper in BF
Somogyi effect
77
Results when evening dose of intermediate-acting insulin is low Hypergly in 3 and 7am
Waning of insulin dose
78
Low insulin sn b/w 6 and 7am d/t GH secretion | 3am glucose normal
Dawn phenomenon
79
Insulin sensitizers
Biguanides | Thiazolidinediones
80
Growth hormone; used in AIDS wasting and conditions involving short stature
Somatropin

Pharmacology (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions