Platelets Flashcards
What are the 4 functions of platelets
- Maintenance of vascular integrity by sealing minor endothelial deficiencies.
- Helping to arrest bleeding by the formation of platelet plugs following endothelial constriction.
- Contributing membrane lipid procoagulant activity to facilitate secondary hemostasis (coagulation) and fibrin formation. ( platelet factor 3)
- Promoting vascular healing through platelet derived growth factor (PDGF).
and smooth muscle production.
Where are platelets produced
produced in the bone marrow from megakaryocytes.
Formed by megakaryocytic cytoplasmic demarcation.
What does thrombopoietin do
Regulates the development of megakaryocytes from hemopoietic stem cells.
Where is thrombopoietin produced
The source of thrombopoietin is uncertain but appears to involve liver, endothelial cells, and fibroblasts.
How long do platelets live
Platelets have a variable but finite intravascular lifespan in the dog and cat of 3 to 7 days.
How are platelets destroyed
Effete platelets are phagocytized by macrophages of the mononuclear phagocyte system.
What is a decreased platelet count called
Thrombocytopenia
What is the name of Platelet Function Disorders
Thrombocytopathia or Thrombopathia
What can cause thrombocytopathia
Von Willebrands and NSAIDS
What is MPV
mean platelet volume
What is PCT
platelet crit
What is PDW
platelet distribution width
