Platelet Disorders

Question 1

Defect in Gp1b

Answer 1

Bernard Soulier’s Disease

Question 2

All Platelet Disorders have Normal what? and Increased what?

Answer 2

1. Normal PTT, PT

2. Increased BT

Question 3

Defect in platelet to-vwF adhesion defect?

Answer 3

Bernard Soulier (Big Sucker)

Question 4

Bernard Soulier’s Disease is what kind of defect?

Answer 4

Adhesion

Question 5

platelet disorders leads to what kind of bleeding? vs Coagulation disorders

Answer 5

Platelet disorders=>epitaxis, mucosal bleeding

Coagulation disorders=>deep bleeding

Question 6

What disorders and drugs affect II/IIIb?

Answer 6

Glanzmann thrombasthenia
Immune thrombocytopenia

Abciximab, eptifibatide, tirofiban.

Question 7

Glanzmann thrombasthenia is due to?

Answer 7

Decreased II/IIIb

Question 8

Immune thrombocytopenia is due to?

Answer 8

IgG antibodies against II/IIIb

Question 9

MCC of thrombocytopenia?

Answer 9

ITP

Question 10

ITP means?

Answer 10

In two places

Question 11

ITP labs?

Answer 11

Increased megakaryocytes

Question 12

TTP mnemonic?

Answer 12

Thirteen Thrombosis Problem

Question 13

TTP pathogenesis?

Answer 13

Inhibition of ADAMTS 13 (vWF metalloprotease)=> large vWF platelters=>thrombosis=>schistocytes and hemolysis

Question 14

TTP Labs?

Answer 14

LDH and schistocytes

Question 15

TTP symptoms?

Answer 15

FAT RN

Fever, Anemia (MAMA) Thrombocytopenia, Renal and Neurologic

Question 16

With Splenectomy you eliminate both?

Answer 16

primary source of ab and site of destruction