Macrocytic Anemia Flashcards
1
Q
Megaloblastic anemia leads to?
A
hypersegmented neutrophils , glossitis.
2
Q
Folate vs B12 def?
A
Folate: Increased homocysteine, normal methylmalonic acid and No neurologic symptoms
B12=>Increased homocysteine, Increased methylmalonic acid and neurologic symptoms (Subacute degeneration)
3
Q
Subacute degeneration?
A
You lose DCML and Lateral Corticospinal Tract
4
Q
Folate is absorbed in the?
A
Jejunum
5
Q
Where is B12 absorbed?
A
Ileum
6
Q
B12 def takes?
A
Years to develop
7
Q
Orotic Aciduria vs Orthinine Trantranscarbamylase deficiency?
A
Orotic Aciduria=>No Hyperammonium
Orthinine Trantranscarbamylase deficiency=>urea cycle=> increased orotic acid+hyperammonia
