Leukemia Flashcards
ALL age?
Acute=>
CLL/SLL age?
> 60 y/o
AML age?
Median of life=>65 y/o
CML age?
Median age of life=>65 y/o
ALL associated with?
Down Syndrome
ALL marker?
+tdt
TdT is a? and a marker of?
DNA polymerase/marker of pre-T and pre-B cells
Thymic mass/Mediastinal mass in a teenager?
T-ALL
B-ALL vs T-ALL?
B-ALL=>CD 10, 19, 20 marker; 12;21 translocation
T-ALL=> NO CD 10
CLL/SLL marker?
CD20 and CD5
CLL what cells do you get?
Smudge cells
Hairy cell leukemia age?
Adults; Mature B-Cell tumor in the elderly
Hairy cell leukemia histology?
filamentous, hair-like projections
HAIR TRAPs Bugs (B-cell tumor)
Hairy cell leukemia Stain?
TRAP (tartrate-resistant acid phosphatase ⊕)
Hairy cell leukemia Tx?
cladribine
In hairy cell leukemia, you get splenomegaly due to?
Expansion of the red pulp
AML marker?
MPO (peroxidase)=>auer rods
AML is due to?
Alkylating agents
AML M3 translocation?
t15;17
AML Receptor? and Tx?
M3 AML subtype responds to all-trans retinoic acid (Vit. A)
Acute Monocytic leukemia lacks what thing and has what thing compared to AML?
Lacks MPO
Gains Gum lesions
Acute megakaryoblastic leukemia associated with>
Down Syndrome
CML gene?
(t[9;22], BCR-ABL)=>increased tyrosine kinase activity
CML can lead to?
ALL and AML
Hallmark of CML?
Basophilia
CML tx?
Imatinib
Cells express S-100 (mesodermal origin) and CD1a?
Langerhans Cell Histiocytosis
Langerhans Cell Histiocytosis histology?
birbeck granules
