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Hem/Onc > Hematology Pharmacology > Flashcards

Hematology Pharmacology Flashcards

1
Q

Streptokinase MOA AE?

A

MOA: Aids conversion to plasmin=>cleaves thrombin and fibrin

AE: Intracranial bleeding/generalizaed bleeding

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2
Q

Antidote to Streptokinase?

A

Aminocaproic acid

Abruptly stop Acute Bleeding

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3
Q

Heparin Antidote?

A

Protamine Sulfate

“Prothrombin”

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4
Q

Heparin MOA?

A

Activator of antithrombin=> decreased thrombin and 10a

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5
Q

Low-molecular-weight heparins (e.g., enoxaparin, dalteparin) and fondaparinux act more on?

A

10a

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6
Q

HIT?

A

development of IgG antibodies against heparin- bound platelet factor 4 (PF4)

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7
Q

Argatroban, bivalirudin, dabigatran MOA?

A

Inhibits Thrombin

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8
Q

Warfarin MOA?

A

Interferes with γ-carboxylation of vitamin K– dependent clotting factors II, VII, IX, and X, and proteins C and S.

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9
Q

Warfarin metabolism affected by?

A

epoxide reductase gene (VKORC1).

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10
Q

Warfarin vs Heparin?

A

Heparin=>Water soluble, pregnancy friendly, Blood=site of action=>inhibits coagulation in a test tube

Warfarin=>Lipid soluble, small, tetragenic, Liver

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11
Q

Apixaban, rivaroxaban MOA?

A

ApiXaban, rivaroXaban=>10a inhibitors

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12
Q

Apixaban, rivaroxaban AE?

A

Bleeding=>no reversible agent

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13
Q

Clopidogrel, prasugrel, ticagrelor (reversible), ticlopidine are?

A

ADP receptor inhibitors

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14
Q

Clopidogrel MOA?

A

irreversibly blocking ADP receptors

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15
Q

ticlopidine AE?

A

Neutropenia

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16
Q

Cilostazol, dipyridamole are?

A

PDE III inhibitors=>vasodilation

17
Q

Cilostazol, dipyridamole AE?

A

Nausea, Headache and flushing

18
Q

GP IIb/IIIa inhibitors?

A

Abciximab, eptifibatide, tirofiban.

19
Q

GP IIb/IIIa inhibitors MOA?

A

Bind to the glycoprotein receptor IIb/IIIa on activated platelets,

20
Q

GP IIb/IIIa inhibitors Use?

A

percutaneous transluminal coronary angioplasty.

Hem/Onc (17 decks)

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