Chronic myeloproliferative disorders Flashcards
1
Q
What is involved in hematopoietic growth factor signaling?
A
JAK2
2
Q
Increased hematocrit due to JAK2?
A
Polycythemia vera
3
Q
Presentation of Polycythemia vera?
A
itching after hot shower (due to increased basophils)=>basophilia
4
Q
Myelofibrosis MOA?
A
Obliteration of bone marrow due to increased fibroblast activity
5
Q
Myelofibrosis cell?
A
Tear drop cell
6
Q
All Chronic Conditions have increased JAK2 except?
A
CML
7
Q
In myelofibrosis, do you have increased or decreased RBC?
A
Decreased
8
Q
In CML, do you have increased or decreased RBC?
A
Decreased
9
Q
Polycythemia vera Labs?
A
Increased RBC mass and volume but Decreased EPO Levels
10
Q
Increased EPO levels but decreased O2 saturation?
A
High altitude, CV or Lung disease
11
Q
Increased EPO levels and normal saturation?
A
RCC
