Mixed platelet and coagulation disorders Flashcards
1
Q
MC inherited Coag. Disorder?
A
vWF disease
2
Q
Lab values for vWF disease?
A
Increased bleeding and Increased PTT
3
Q
Why increased PTT?
A
You need factor 8 to stabilize vWF=>Increased PTT
4
Q
vWF dx?
A
Ristocetin cofactor assay=>decreased agglutination is diagnostic
5
Q
vWF tx?
A
desmopressin
6
Q
DIC MOA?
A
pathologic activation of coag. cascade=>diffuse clotting=>def in clotting factors=>bleeding states
7
Q
Labs for DIC?
A
Increased BT=>Diffuse clotting=>Decreased Platelet Count=>increased PT and PTT (bleeding)
8
Q
DIC Causes?
A
Sepsis Trauma=>rattle snake bite OBGYN=>tissue thromboplastin Pancreatitis Malignancy Nephrotic syndrome Transfusion
9
Q
DIC dx?
A
Dimer=>fibrin split product
