Plasma disorders Flashcards
2 proteins that can cause amyloid deposition
kappa and lambda light chain
OMM and plasma cell disorders?
be very careful. brittle bones
Hyperviscosity is most common with what plasma cell disorder
macroglobulinemia
Rockstar: patients with an A:G ratio <1
suggest plasma cell disorder like MGUS or myeloma
what should total protein normally be
aobut 7
fat pad biopsy
amyloidosis
management of solitary plasma cytoma
radiation
what do you use for staging of multiple myeloma?
- skeletal X ray survey
- bone marrow aspirate biospy . . see increase in bone marrow plasma cells above 10% and abnormal looking
- DO NOT USE bone scan
frontline therapy to cover malignancy and hypercalcemia in MM
bisphosphonates
Normal Ca lever
8.5-10.5
fundascopic sausage linking
hyperviscosity . . Waldenstrom
management of Waldenstrom macroglobulinemia
- Plasmaphoresis for hyperviscosity
- Treat underlying disease along lines as MM . . Rituximab has been effective
presence of M protein consisting of a portion of Ig heavy chain in serum, urine, or both
Heavy chain disease
When does crycoglobulinemia occur
cold
defined as bone marrow monoclonal plasma cell less than 10% in the setting of a paraprotein lessthan 3g/L and absence of end organ damage
MGUS
