pediatric leukemia and lymphoma

Question 1

Most common cancer in adolescents?

Answer 1

lymphoma

Question 2

Most common malignancy in age group 15-19

Answer 2

Hodgkin Lymphoma

Question 3

B symptoms: unexplained fever 39C or 103F
Wt loss
Drenching night sweats

Answer 3

hodgkin lymphoma

Question 4

Any patient with persistent unexplained lymphadenopathy unassociated with an obvious underlying inflammatory or infectious process should undergo chest radiography to rule out a mediastinal mass before undergoing lymph node biopsy

Answer 4

diagnosis of HL

-excisional LN biopsy preferred

Question 5

This accounts for 60% of lymphomas in children and adolescents?

Answer 5

NHL

Question 6

What are the inherited or acquired immune deficiencies that can lead to NHL?

Answer 6

• SCID

- Wiscott-Aldrich syndrome (X-linked recessive)

Question 7

• recurrent sinopulmonary infections
• exzema
• Bleeding (secondary to thrombocytopenia)

Answer 7

Wiscott-Aldrich syndrome

Question 8

This NHL commonly manifests as abdominal or head and neck disease with involvment of the bone marrow or CNS

Answer 8

Burkitt

Question 9

These result from malignant transformation and clonal expansion of hematopoietic cells at an early stage of differentiation that are then unable to undergo further maturation

Answer 9

leukemia