Hubbard leukemia

Question 1

what toxin is linked to AML

Answer 1

benzene

Question 2

Treatment related AML in patients who received chemo for prior cancers . . what kind of agents?

Answer 2

alkylators

Question 3

What kind of leukemia is NOT caused by radiation

Answer 3

CLL

Question 4

in older patients with mild pancytopenia and macrocytosis, if you offer the diagnosis of these 2 things you will look like a rockstar

Answer 4

• myelodysplasia

- early AML

Question 5

transfustion for APL

Answer 5

t(15;17)

Question 6

in the acute leukemias (especially ALL) patients often complain of what

Answer 6

bone pain

Question 7

• cutaneous manifestation of AML
• biopsy demonstrates myeloblasts in the dermis
• can be confused with pyoderma gangrenosum

Answer 7

Sweet’s syndrome aka acute febrile neutrophilic dermatosis (AFND)

Question 8

how do you treat Sweet’s syndrome (AFND)

Answer 8

manage the AML

Question 9

azurophilic rods in the cytoplasm of patients with AML

Answer 9

Auer rods

Question 10

when Auer rods resemble a bundle of sticks in some patients with APL

Answer 10

faggot cells

Question 11

What types of AML most commonly have gingival hypertrophy

Answer 11

M4 (acute myelomonocytic)

M5 (Acute monocytic)

Question 12

Multiple smudge cells are seen in what

Answer 12

CLL

Question 13

remnant of mitiotic spindle usually in erythrocytes

Answer 13

cabot rings

Question 14

foamy big cells in bone marrow and not in peripheral blood

Answer 14

Gaucher cells

Question 15

normal LDH

Answer 15

under 250-300

Question 16

normal uric acid

Answer 16

7

Question 17

when are schistocytes seen?

Answer 17

microangiopathic hemolytic anemia like TTP and HUS

Question 18

normal level of fibrinogen

Answer 18

400

Question 19

when do you see increased lysozyme levels

Answer 19

monocytic leukemias . . M4 and M5

Question 20

patient with DIC and APL should be treated with what?

Answer 20

• All-trans retinoic acid (ATRA) or

- arsenic trioxide

Question 21

what is 2-chlorodeoxyadenosine used for

Answer 21

hairy cell leukemia

Question 22

what is the backbone of induction therapy for ALL

Answer 22

Vincristine and prednisone

Question 23

what is a hypomethylating agent used for myelodysplastic syndrome

Answer 23

Decitabine

Question 24

t(12;21)

Answer 24

All

Question 25

Trisomy 8

Answer 25

MDS . .better prognosis

Question 26

t(8;21)

Answer 26

M1 and M2 AML

Question 27

5q-

Answer 27

MDS . . will respond to an imide drug

Question 28

neurological symptoms in ALL due to what

Answer 28

Leptomeningeal carcinomatosis . . . 35% of ALL patients

Question 29

Diplopia can be found in what leukemia? | What nerve is susceptible?

Answer 29

ALL | CN6

Question 30

t(4;11)

Answer 30

Classic L2 ALL . . most common type of acute leukemia

Question 31

7q-

Answer 31

MDS

Question 32

inv(16)

Answer 32

MDS . . . also AML

Question 33

treatment for diplopia in ALL

Answer 33

intrathecal methotrexate

Question 34

Catheter inserted b neurosurgeon into a lateral ventricle with a subcutaneous reservoir for delivery of intrathecal therapies. In palliative care, for delivery of intrathecal morphine

Answer 34

Ammaya reservoir

Question 35

what does kikuchi Disease cause

Answer 35

massive LAD in cervical

Question 36

man comes in with no complaints. only bilateral small cervical adenopathy and elevated WBC and lymphs. . what best test to further evaluate

Answer 36

peripheral blood lymphocyte flow cytometry . . quick and ease

Question 37

TRAP stain of peripheral blood lymphocytes

Answer 37

hairy cell leukemia

Question 38

Rai staging for CLL

Answer 38

0: lymphocytosis only 1: + LAD 2: + organomegaly (spleen and liver) 3: +anemia (Hb less than 11) 4: +thrombocytopenia (less than 100k) 0-1: low risk 2: intermediate 3-4: high risk

Question 39

77 year old with CLL asymptomatic . . treat how

Answer 39

Observation

Question 40

trisomies associated with ALL

Answer 40

4, 10, 17

Question 41

What are the monsomies of AML that carry poor prognosis

Answer 41

5 and 7

Question 42

Treatment of AML

Answer 42

- most with combo of anthracycline (daunorubicin or idarubicin) - AML patients who are older and not candidates for traditional therapy: 5-azacitidine or decitabine

Question 43

treatment of ALL

Answer 43

combo: daunorubicin, vincristine, prednisone, and asparaginase. - if patient has bcr-abl positivity, a tyrosine kinase inhibitor, dasatinib should be added

Question 44

after remission, what should ALL patients receive

Answer 44

CNS prophylaxis so that meningeal sequestration of leukemic cells doesn't develop

Question 45

diagnosis of chronic leukemia

Answer 45

- B cell lymphocytosis>5000 - Coexpression of CD19, CD5 (only in CLL and mantle cell lymphoma) - CLL differentiated from mantle cell lymphoma by expression of CD23 and low expression of surface immunoglobulin and CD20

Question 46

indications for treatment of CLL

Answer 46

- progressive fatigue - symptomatic lymphadenopathy - anemia - thrombocytopenia

Question 47

initial treatment for CLL in under 70 patients

Answer 47

-combo of fludarabine plus rituximab with or without cyclophosphamide

Question 48

treatment of older frail patients with CLL that have indications for treatment

Answer 48

chlorambucil orally every 3 weeks for 6 months

Question 49

What can be used in patients with relapsed/refractory CLL in those with deletion of 17p

Answer 49

ibrutinib

Question 50

Ph chromosome

Answer 50

9,22 fusion

Question 51

Treatment of CML

Answer 51

- targeted at bcr abl tyrosine kinase - first gen: imatinib - 2nd gen: dasatinib and nilotinib - pts on TK inhibitors should be monitored with a quantitative PCR assay to check levels of bcr/abl

Question 52

Treatment for Hairy Cell leukemia

Answer 52

-IV cladribine daily for 7 days