Chemo 5

Question 1

Cell cycle non specific drugs are _____ dependent

Answer 1

Dose . . .

cell cycle specific drugs are more schedule dependent

Question 2

What are the triazenes and what do they do

Answer 2

• Dacarbazine
• Procarbazine
• Temozolomide

-DNA alkylation. Methylation of Guanasine O6, N7

Question 3

What are the Nitrosoureas and what do they do?

Answer 3

Carmustine
Lomustine

-Alkylation THEN crosslinking guanosine O6, N7. also Protein carbamoylation

Question 4

What is streptozocin used for

Answer 4

insulinomas

Question 5

What are Nitrosoureas used for

Answer 5

Brain tumors

Question 6

What is Dacarbazine used for

Answer 6

metastatic melanoma

Question 7

what is Procarbazine used for

Answer 7

Malignant glioma

Question 8

What is temozolomide used for

Answer 8

Treatment resistant glioma and astrocytoma

Question 9

What are the nitrogen mustards?

Answer 9

• cyclophosphamide
• Ifosfamide
• Mechlorethamine

Question 10

how are Cyclophosphamide and Ifosfamide activated

Answer 10

CYP450

Question 11

What does Melphalan target?

Treat?

Answer 11

Phenylalanine transporters

-Multiple myeloma

Question 12

What route of administration is Chlorambucil?

What does it treat?

Answer 12

oral

-CLL

Question 13

What does busulfan treat

Answer 13

CML

Question 14

What does Estramustine treat

Answer 14

Advanced prostate cancer

Question 15

what is the M in MOPP treatment for Hodgkin disease

Answer 15

Mechlorethamine

Question 16

What happens if you miss the vein or infuse Mechlorethamine too fast?

Answer 16

blisters or necrosis

Question 17

What is the active metabolite of cyclophosphmide?

Toxic one?

Answer 17

• phosphoramide

- Acrolein: urotoxix to bladder

Question 18

What CYP450s metabolize cyclophosphamide and Ifosfamide?

Answer 18

2B6 and 34A

Question 19

Ifosfamide has similar metabolites as Cyclophosphamide except it also has one extra. . what is it

Answer 19

-Chloroacetaldehyde (Neurotoxicity)

Question 20

What is given prophylactically before administration of cyclophasphamide to diminish the toxic effect of Acrolein on the bladder

Answer 20

MESNA

Question 21

What is used for castration resistant prostate cancer?

What is the complication?

Answer 21

• Estramustine

- Thromboembolic events

Question 22

route of administration of Carmustine?

Lomustine?

Answer 22

IV

oral

Question 23

Dacarbazine (IV) and Temozolomide (PO) both have what same activated metabolite

Answer 23

Methyltriazene imidazole carboximide

Question 24

Does Dacarbazine or Temozolomide penetrate into the CNS well

Answer 24

Temozolomide

Question 25

What enzyme in tumors influences the efficacy of Temozolomide

Answer 25

O6-MGMT

Question 26

What is a biomarker for temozolomide efficacy

Answer 26

Epigenetic silencing of MGMT . . we want it to be silenced

Question 27

What are the organo-platinum drugs

Answer 27

• Cisplatin
• Carboplatin
• Oxaloplatin

Question 28

What is cisplatin used for

Answer 28

Testicular cancer

Question 29

What is Carboplatin used for

Answer 29

Ovarian cancer

Question 30

What is Oxaloplatin used for

Answer 30

colorectal cancer

Question 31

What is the dose limiting toxicity of cisplatin

Answer 31

• Acute renal failure

- Ototoxicity later in life and is permanent

Question 32

What is the dose limiting toxicity of Oxaloplatin

Answer 32

cold induced neuropathy . . don’t give ice cubes

Question 33

how does cisplatin enter cells

Answer 33

diffusion and Cu2+ transporter

Question 34

What kind of crosslinking does cisplatin do that is difficult for the tumor to repair

Answer 34

INTRA strand. . . . same strand