pediatric platelet disorders

Question 1

platelet count when primary hemostasis is impaired

Answer 1

below 75k

Question 2

platelet count when spontaneous bleeding occurs

Answer 2

below 50k

Question 3

platelet count when noticeable/clinically significant bleeding occurs

Answer 3

20k

Question 4

platelet count when life threatening hemorrhage occurs

Answer 4

10k

Question 5

What is the most common cause of isolated thrombocytopenia in otherwise well children

Answer 5

acute ITP

Question 6

Sudden onset of bruising and bleeding in an OTHERWISE HEALTHY CHILD, and 50% after viral illness

Answer 6

acute ITP

Question 7

what is the time frame the separates acute from chronic ITP

Answer 7

6 months

Question 8

peripheral smear with ITP

Answer 8

• schistocytes
• +direct coombs
• Fibrin degradation products and fibrinogen

Question 9

describe the treatment for ITP

Answer 9

• No treatment alter natural history
• Prednisone, IVIG, anti-D immunoglobulin can increase count
• focus on keeping count above 20

Question 10

What 2 diseases cause consumption of platelets resulting from endothelial injury and vasculitis

Answer 10

HUS and TTP

Question 11

Compare and contrast HUS and TTP

Answer 11

TTP: adults, thrombocytopenia and hemolytic anemia
HUS: children, E. coli, microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure

Question 12

only curative treatment of chronic ITP

Answer 12

splenectomy

Question 13

if pancytopenia and maybe no LAD or constituational symptoms

Answer 13

aplastic anemia

Question 14

pancytopenia with bloody diarrhea and maybe edema

Answer 14

HUS