Plasma cells Flashcards
Where are B cells derived from?
Bone marrow
- pluripotent haemopoietic stem cells
B cells form part of the innate/adaptive immune system?
Adaptive
What are the 2 main roles of B cells
Antibody production
Act as APCs
What are Ig’s ?
Antibodies produced by B cells
Name a Ig dimer
IgA
Name a Ig Pentamer
IgM
Name 3 Ig Monomers
IgD, IgE, IgG
The variable element of Ig is generated from?
V-D-J region recombination
Immature B cells with Ig on their surface do what?
Exit the bone marrow ready to meet their target
Once a B cell has left the bone marrow and is now in the periphery, where does it travel to
The follicle germinal centre of the lymph node as this is where it identifies an antigen
B cells can mature as ____ cells or may circulate as ______ cells
Mature as plasma cells
Circulate as Memory B cells
Each Ig is named after the type of heavy/light chain it has?
Heavy
Plasma cell - function
Pumps out antibody
Plasma cell - histological appearance
Clock face nucleus on H+E
Plentiful blue cytoplasm
Pale perinuclear area
Normally, the B cell and plasma cell repertoire will have several clones contributing to make antibodies of different specificity. Ie polyclonal. True or false?
True
