Plasma Cell Disorders/Dyscrasias Flashcards
Which IL promotes plasma cells generation
IL-6
“plasma” has 6 letters in it!
How does multiple myeloma cause osteoclastic lesions
secretes osteoclast-activating factor
activation of RANK receptor
M-spike in multiple myeloma most commonly made up of which immunoglobulins
IgG
if not IgG then likely IgA
Blood smear in multiple myeloma
rouleaux formation
Serum labs in multiple myeloma
elevated protein
order serum protein electrophoresis
M-spike on electrophoresis
Monoclonal gammopathy of undetermined significance
increased serum protein + M-spike
but no other Sx of multiple myeloma
1% risk of developing multiple myeloma each year
Kidney damage in multiple myeloma
AL amyloidosis
due to light chain deposition
IgM in M-spike on protein electrophoresis
Waldström Macroglobulinemia
macro because IgM in pentameric form
Waldström Macroglobulinemia is a lymphoma
Sx of Waldström Macroglobulinemia
from hyperviscosity
- visual and neurologic defects from aggregation
- bleeding from defective platelet aggregation
Acute Tx of Waldström Macroglobulinemia
plasmaphoresis
remove IgM pentamers from blood
Langerhans cell histiocytosis
etiology
derived from marrow monocytes
Labs in Langerhans cell histiocytosis
CD1a+ and S100+
What are Langerhans cells
specialized skin dendritic cells
