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Ch. 06 WBC Disorders > Acute Leukemias > Flashcards

Acute Leukemias Flashcards

1
Q

Acute leukemia with

tDt + nuclear marker

A

ALL

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2
Q

ALL is more common in children/adults

esp. this population

A

children

more common in Down syndrome after age 5 yr

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3
Q

B-ALL markers

A

CD10, CD19, CD20

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4
Q

Special treatment considerations in ALL

A

need to give prophylactic chemo to CSF and scrotum before systemic
because chemo cannot cross those two barriers normally

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5
Q

T-ALL markers

A

CD2 to CD8

ie CD3, CD4, CD7, etc

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6
Q

CD10 in acute leukemia

type

A

B-ALL

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7
Q

CD3 in acute leukemia

type

A

T-ALL

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8
Q

CD7 in acute leukemia

type

A

T-ALL

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9
Q

CD19 in acute leukemia

type

A

B-ALL

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10
Q

CD20 in acute leukemia

type

A

B-ALL

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11
Q

CD4 in acute leukemia

type

A

T-ALL

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12
Q

Presentation of B-ALL

A

younger child

maybe Down syndrome if 5+ y/o

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13
Q

Presentation of T-ALL

A

teenager with thymic mass
all T’s
*this is a lymphoma because it occurs as a mass in the thymus

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14
Q

CD10 in acute leukemia

type

A

B-ALL

**T-ALL does not express CD10

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15
Q

t(12;21)

A

B-ALL
has good prognosis
how could it not–the numbers are just flipped

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16
Q

t(9;22)

A

Philedelphia chromosome
B-ALL
has poor prognosis
more common in adults

17
Q

Auer rods are classically found in

and are composed of

A

AML

composed to myeloperoxidase

18
Q

Classical marker of AML

A

MPO–myeloperoxidase

19
Q

AML population

A

older adults

20
Q

Classic translocation in AML

A

t(15;17) = acute promyelocytic leukemia
retinoic acid receptor, mutation disrupts ability for cells to mature
**Tx: ATRA, all-trans retinoic acid

21
Q

Tx of classic AML

A

ATRA

all-trans retinoic acid

22
Q 
Acute promyelocytic leukemia in AML
you should know all this
characteristic translocation
major complications
Tx
A

t(15;17), in RAR (retinoic acid receptor)–does not allow for maturation of cells
DIC is major complication b/c promyelocytes contain coagulation factors
Tx is ATRA (all-trans retinoic acid)

23
Q

Acute monocytic leukemia (AML)

presentation

A

infiltration of gums

*may not have MPO

24
Q

Acute megakaryoblastic leukemia (AML)

presentation

A

Down syndrome under 5 y/o

*may not have MPO

25
Q

Down syndrome acute leukemias

which ones when

A

before age 5: megakaryoblastic leukemia (AML)

after age 5: T-ALL

26
Q

Basics about CD markers in B- vs T-ALL

A

T-cell is less than CD10

B-cell is CD10 and greater ie CD10, 19, 20

Ch. 06 WBC Disorders (8 decks)

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