Hodgkin Lymphoma

Question 1

Markers in Hodgkin

Answer 1

CD15 and CD30 (15 x 2 = 30, two eyes from RS cell)
NOT CD20
CD20 is present in non-Hodgkin lymphomas

Question 2

Pathology of Reed-Sternberg cells

Answer 2

secrete a bunch of cytokines

• makes B-Sx
• attracts other inflammatory cells –> lymphadenopathy
• fibrosis

Question 3

Which kidney disease is associated with Hodgkin lymphoma

Answer 3

minimal change disease
because RS cells secrete a bunch of cytokines
cytokines lead to effacement of foot processes causing nephrotic syndrome

Question 4

Nodular sclerosis subtype of Hodgkin

histology

Answer 4

node divided by fibrotic bands
RS cells present in lake-like spaces
“lacunar cells”

Question 5

Classic CBC finding of Hodgkin disease

Answer 5

eosinophilia
especially in mixed-cell type
RS cells secrete IL-5 –> eosinophils

Question 6

Special things to remember about other subtypes of Hodgkin lymphoma
lymphocyte-rich
mixed cellularity
lymphocyte depleted

Answer 6

lymphocyte-rich: best prognosis
mixed cellularity: eosinophilia via IL-5 from RS cells
lymphocyte-depleted: worst prognosis, HIV and elderly association