Chronic Leukemias

Question 1

CLL

cell type and markers

Answer 1

B-cells

CD5 and CD20

Question 2

CLL classic pathology findings

Answer 2

smudge cells on smear
CD5+ and CD20+
CD5+ is kind of weird because that’s less than 10, which would normally be a T-cell marker, but this one is a B-cell marker

Question 3

Complications of CLL

Answer 3

hypogammaglobulinemia: infection
autoimmune hemolytic anemia: type II hypersensitivity
transformation to acute: Richter transformation

Question 4

Hairy cell leukemia

everything to know is in stain name

Answer 4

TRAP stain: tartrate resistant acid phosphatase
*stains hairy cytoplasmic processes
traps everything in BM –> dry tap
trapped in RED pulp of spleen –> no lymphadenopathy

Question 5

Tx of hairy cell

Answer 5

2-CDA/cladribine

adenosine deaminase inhibitor, adenosine accumulates to toxic levels in neoplastic B-cells

Question 6

Adult T-cell leukemia/lymphoma association

Answer 6

HTLV-1
human T-cell leukemia virus-1
in Caribbean and Japan

Question 7

Presentation of adult T-cell leukemia

Answer 7

punched-out lytic bone lesions
+
rash
*lytic like MM, but with rash!

Question 8

Adult T-cell leukemia

cell type

Answer 8

CD4+

Question 9

Mycosis fungoides

cell type

Answer 9

CD4+

Question 10

Mycosis fungoides

produces aggregates in epidermis called

Answer 10

Pautrier microabscesses

Question 11

Smear of mycosis fungoides

Answer 11

cerebriform nuclei = Sezary cells