Leukopenia and Leukocytosis Flashcards
If infectious mono isn’t due to EBV then it’s due to
CMV
Which odd infection causes lymphocytosis
Bordetella pertussis
produces lymphocytosis-promoting factor, prevents lymphocytes from entering node
Hematopoietic stem cell marker
CD34
GM-CSF vs G-CSF
GM-CSF: granulocyte (and) monocyte colony stimulating factor
G-CSF: granulocyte colony stimulating factor
Immature neutrophils have few of these
CD16
Fc receptor
*not as effective as normal CD16+ neutrophils
*you have to be 16 to drive, so that’s how neutrophils get to drive to Fc receptors is via CD16/Fc receptor
Severe infection and neutrophils
may cause neutropenia
because neutrophils leave circulation to invade the infection
neutrophils are low in the blood
Which cell in the body is most sensitive to radiation
lymphocytes
Eosinophilia classically seen in
Hodgkin lymphoma
Basophilia classically seen in
CML
EBV infects which sites
oropharynx
liver: hepatitis
B-cells: risk of B-cell lymphoma
CD8+ T-cell response leads to hyperplasia of
node paracortex
periarterial lymphatic sheath of spleen
Where are CD8+ T-cells mostly found in the lymph node
paracortex
- next to medulla
- makes sense because they have to get out into circulation
Where are B-cells normally found in the lymph node
cortex
- outer part
- makes sense because they just sit there and make Ab, don’t have to get out into circulation
Classic cell in EBV
atypical lymphocyte
*looks like monocyte, that’s where infectious mono got its name
Screening in EBV
IgM heterophile Ab
