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Bacterial Infections > Plague > Flashcards

Plague Flashcards

1
Q

Why do fleas die from Y. Pestis?

A

GI tract blockage

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2
Q

What is the pathophysiology of infection with Y. Pestis?

A

LCR effector proteins aka YOPS casues cytoskeleton disruption which interferes with phagocytosis. It also prevents proinflammatory cytokine synthesis and inhibits oxidative outbursts.and enhances apoptosis. The F1 capsular protein protects the organism from phagocytosis.

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3
Q

What is the incubation period of Bubonic Y. Pestis?

A

2 to 6 days

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4
Q

What is the incubation period of Pneumonic Y. Pestis?

A

2 to 4 days

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5
Q

What other types of Y Pestis infections exist?

A

Pharyngitic and Meningitic

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6
Q

How to diagnose Bubonic Plague?

A

Aspirate enlarged lymph nodes and exam under microscope.

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7
Q

What is the treatment of Y. Pestis?

A

Streptomycin 1 gm per day

Gentamicin 5 mg/kg per day

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8
Q

What animals harbor plague in addition to rats?

A 
Black Bears
Cats
Coyotes
Dogs
Fox
Martens
Racoons
Skunks
Weasels
Wolverines
Wolves
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Bacterial Infections (14 decks)

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