pituitary/hypothalmic drugs Flashcards
1. Classify agents based upon whether they are used for replacement therapy, supra-physiological dosing, to control or modify excess endogenous secretions, or for diagnostic purposes. 2. List the prototype drugs having gonadotropin releasing activity, describe their mechanism of action and list their major side effects and clinical uses. 3. List the prototype drugs having FSH and/or LH activity, describe their mechanism of action and list their major side effects and clinical uses. 4. Describ
gonadorelin
synthetic GnRH
leuprolide
hi-potency GnRH analoge
histrelin
super hi-potency GnRH analouge
naferelin
nasal spray super hi-potency GnRH analouge
Menotropin
FSH AND LH agonist
follitropin alfa
FSH agonist
urofollitropin
FSH-like activity
hCG
LH-like activity
Desmopression
treats diabetes insipidus (nasal spray)
somatropin
treats GH deciency
octreotuide
GHRIH analog
octreouide use
treats acromegaly
bromocriptine use
treats acromegaly
pegvisomant use
treats acromegaly
DDAVP another name for
desmopressin
induction and stimulation of labor
oxytocin
oxytocin use
induction of labor and stimulation of milk :let down”
MOA of pegvisomant
binds to GH receptors, blocks GH from activating receptors and decreses production of IGF-1
somatrem
GH analog
Somatropin
hGH analog
sermorelin
synthetic GHRH analog
somatostatin/GHIRH effects
inhibits GH, ACTH, TSH, insulin, Glucogon and GUI hormones
drugs that increase prolactin
antipsycotics, estrogen, testosterone, TRH, opiates
drugs that decrease prolactin
L-dopa, bromocriptine, MAOis
