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Endocrine > pituitary/hypothalmic drugs > Flashcards

pituitary/hypothalmic drugs Flashcards

1. Classify agents based upon whether they are used for replacement therapy, supra-physiological dosing, to control or modify excess endogenous secretions, or for diagnostic purposes. 2. List the prototype drugs having gonadotropin releasing activity, describe their mechanism of action and list their major side effects and clinical uses. 3. List the prototype drugs having FSH and/or LH activity, describe their mechanism of action and list their major side effects and clinical uses. 4. Describ

1
Q

gonadorelin

A

synthetic GnRH

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2
Q

leuprolide

A

hi-potency GnRH analoge

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3
Q

histrelin

A

super hi-potency GnRH analouge

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4
Q

naferelin

A

nasal spray super hi-potency GnRH analouge

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5
Q

Menotropin

A

FSH AND LH agonist

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6
Q

follitropin alfa

A

FSH agonist

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7
Q

urofollitropin

A

FSH-like activity

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8
Q

hCG

A

LH-like activity

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9
Q

Desmopression

A

treats diabetes insipidus (nasal spray)

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10
Q

somatropin

A

treats GH deciency

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11
Q

octreotuide

A

GHRIH analog

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12
Q

octreouide use

A

treats acromegaly

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13
Q

bromocriptine use

A

treats acromegaly

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14
Q

pegvisomant use

A

treats acromegaly

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15
Q

DDAVP another name for

A

desmopressin

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16
Q

induction and stimulation of labor

A

oxytocin

17
Q

oxytocin use

A

induction of labor and stimulation of milk :let down”

18
Q

MOA of pegvisomant

A

binds to GH receptors, blocks GH from activating receptors and decreses production of IGF-1

19
Q

somatrem

A

GH analog

20
Q

Somatropin

A

hGH analog

21
Q

sermorelin

A

synthetic GHRH analog

22
Q

somatostatin/GHIRH effects

A

inhibits GH, ACTH, TSH, insulin, Glucogon and GUI hormones

23
Q

drugs that increase prolactin

A

antipsycotics, estrogen, testosterone, TRH, opiates

24
Q

drugs that decrease prolactin

A

L-dopa, bromocriptine, MAOis

25
Q

tx for hyperprolactinemia

A

bromocriptine

26
Q

effect of prolactin on estrogen/testosterone

A

decreases

27
Q

short term treatment effect of GnRH analogs

A

stimulates gonadotropins

28
Q

long term treatment effect of GnRH analogs

A

inhibits gonadotropins

29
Q

use of gonadorelin

A

measures LH respons

30
Q

male leydig cells produce

A

testosterone

31
Q

female corpus luteum produces

A

induces ovulation, secretion estrogen and progesterone

32
Q

drugs used to diagnose thyroid issues

A

thyrotropin, protirelin

33
Q

ACTH drugs used as diagnostics

A

corticotropin, cosyntropin

Endocrine (13 decks)

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