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Endocrine > Estrogens and progestins > Flashcards

Estrogens and progestins Flashcards

1
Q

most potent natural estogen

A

estradiol

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2
Q

estrogen drug with first pass effect

A

estradiol

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3
Q

administration of estradiol

A

oral, transdermal, transvaginal

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4
Q

equine conjugated estrogen

A

estrone

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5
Q

most common estrogen therapy

A

estrone

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6
Q

used for vasomotor sx of estrigen deficiency

A

cenestin (synthetic estrogen)

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7
Q

pro-drug concerted to ethynyl estradiol

A

mestranol

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8
Q

increased risk of vaginal/cervical adenocarcinoma

A

DES

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9
Q

non-steroidal estrogen

A

DES

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10
Q

uses of estrogens

A 
OCP
menopause
Osteoporosis
breast cancer
prostate cancer
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11
Q

uses of estrogens that may have high risks

A

menopause and osteoporosis

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12
Q

adverse effects of estrogens

A 
nausea
breast engorgement
endometrial hyperplasia and cancer
birth defects
possibly headaches and breast cancer
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13
Q

competetive estrogen antagonists

A

clomiphene and tamoxifen

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14
Q

inhibitors of estrogen sythesis

A

leuprolide and GnRH analogs

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15
Q

physiological antagonists

A

progestins and androgens

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16
Q

tamoxifen class

A

SERM

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17
Q

MOA of tamoxifen

A

competive partial agonist of estrogen in the breast - blocks the receptor

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18
Q

adverse effects of tamoxifen

A

may increase endometrial cancer
vasomotor sx
n/v

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19
Q

tissue at which tamoxiphen is BOTH more efficious and more potent

A

endometrium

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20
Q

tissue at which tamoxiphen is less efficious and more potent

A

breast

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21
Q

SERM used for postmenopausal osteoporosis

A

raloxifine

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22
Q

effects of raloxafine

A

estrogenic effect on bone

antogonstic effect on uterus and breast

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23
Q

infertility drugs

A

hMG/hCG

clomiphene

24
Q

administration of hMG/hCG

A

IM

25
Q

effect of hMG

A

increases FSH and LH to stimulate follicular development and maturation

26
Q

effect of hCG

A

LH surge increases ovulation

27
Q

confirms ovulation

A

progesterone

28
Q

pregancy rate for hMG/hCG

A

50%

29
Q

oral infertility drug

A

clomiphene

30
Q

blocks Estrogen receptors in feedback loop

A

clomiphene

31
Q

SE of infertility treatment

A

abdominal pain
ovarian cyst rupture
multiple kids

32
Q

infertility drug more likely to give multiple births

A

hMG/hCG

33
Q

use of IM progesterone

A

endometrial/renal cancer
amenorrhea, abnormal uterine bleeding
IUDs

34
Q

synthetic long-lasting progesterone

A

medroxyprogesterone

35
Q

use of medroxyprogesterone

A

injectable contraceptive

36
Q

SE of medroxyprogesterone

A

irregular bleeding, possible lowered bone density

37
Q

racamatic OC progesterone component

A

norgestrel

38
Q

sub-dermal OC (norplant)

A

levonorgestrel

39
Q

norethindrone

A

Prosterone in OCPs

40
Q

ethynodiol diaetate

A

progesterone OCPs

41
Q

uses of progetrins

A

OCP
dysfunctional uterine bleeding
endometrosis
endometrial, breast, renal cancer

42
Q

adverse effects of progestrins

A

abnormal menstrual bleeding

weight gain, demema, depression

43
Q

contraindications of progestrins

A

pregnancy

44
Q

MOA of mifepristone

A

competitive antagonist at progesterone and glucocorticoid receptors

45
Q

use of mifepristone

A

abortion

46
Q

possible uses of mifepristone

A

meningioma, breast cancer, cushings, glaucoma

47
Q

estogens in combo OCPs

A

ethinyl estradiol/mestranol

48
Q

progestins in Combo OCPs

A 
norgesterel
levonorgesterel
norethindrone
ethyndiol diacetate
desogesteral
norgestimate
drospireone
49
Q

progerterin in Yaz

A

drospirenone

50
Q

MOA of combo OCP

A

supression of ovulation

changes in cervical mucus and endometrium

51
Q

use of mini-pilla

A

when Combo OCPs and contraindicated or not tolerated

52
Q

SE of emergency contraception

A

n/v breast tenderness

53
Q

drugs in emergency contraception

A

levonorgestrel and ethinyl estradiol

54
Q

drugs in plan B

A

levonorgesteral

55
Q

OCP side effects

A

thromboit effects
MI
hypertension
cancer??

56
Q

OCP + this is bad news

A

smoking

Endocrine (13 decks)

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