Estrogens and progestins Flashcards
most potent natural estogen
estradiol
estrogen drug with first pass effect
estradiol
administration of estradiol
oral, transdermal, transvaginal
equine conjugated estrogen
estrone
most common estrogen therapy
estrone
used for vasomotor sx of estrigen deficiency
cenestin (synthetic estrogen)
pro-drug concerted to ethynyl estradiol
mestranol
increased risk of vaginal/cervical adenocarcinoma
DES
non-steroidal estrogen
DES
uses of estrogens
OCP menopause Osteoporosis breast cancer prostate cancer
uses of estrogens that may have high risks
menopause and osteoporosis
adverse effects of estrogens
nausea breast engorgement endometrial hyperplasia and cancer birth defects possibly headaches and breast cancer
competetive estrogen antagonists
clomiphene and tamoxifen
inhibitors of estrogen sythesis
leuprolide and GnRH analogs
physiological antagonists
progestins and androgens
tamoxifen class
SERM
MOA of tamoxifen
competive partial agonist of estrogen in the breast - blocks the receptor
adverse effects of tamoxifen
may increase endometrial cancer
vasomotor sx
n/v
tissue at which tamoxiphen is BOTH more efficious and more potent
endometrium
tissue at which tamoxiphen is less efficious and more potent
breast
SERM used for postmenopausal osteoporosis
raloxifine
effects of raloxafine
estrogenic effect on bone
antogonstic effect on uterus and breast
infertility drugs
hMG/hCG
clomiphene
administration of hMG/hCG
IM
effect of hMG
increases FSH and LH to stimulate follicular development and maturation
effect of hCG
LH surge increases ovulation
confirms ovulation
progesterone
pregancy rate for hMG/hCG
50%
oral infertility drug
clomiphene
blocks Estrogen receptors in feedback loop
clomiphene
SE of infertility treatment
abdominal pain
ovarian cyst rupture
multiple kids
infertility drug more likely to give multiple births
hMG/hCG
use of IM progesterone
endometrial/renal cancer
amenorrhea, abnormal uterine bleeding
IUDs
synthetic long-lasting progesterone
medroxyprogesterone
use of medroxyprogesterone
injectable contraceptive
SE of medroxyprogesterone
irregular bleeding, possible lowered bone density
racamatic OC progesterone component
norgestrel
sub-dermal OC (norplant)
levonorgestrel
norethindrone
Prosterone in OCPs
ethynodiol diaetate
progesterone OCPs
uses of progetrins
OCP
dysfunctional uterine bleeding
endometrosis
endometrial, breast, renal cancer
adverse effects of progestrins
abnormal menstrual bleeding
weight gain, demema, depression
contraindications of progestrins
pregnancy
MOA of mifepristone
competitive antagonist at progesterone and glucocorticoid receptors
use of mifepristone
abortion
possible uses of mifepristone
meningioma, breast cancer, cushings, glaucoma
estogens in combo OCPs
ethinyl estradiol/mestranol
progestins in Combo OCPs
norgesterel levonorgesterel norethindrone ethyndiol diacetate desogesteral norgestimate drospireone
progerterin in Yaz
drospirenone
MOA of combo OCP
supression of ovulation
changes in cervical mucus and endometrium
use of mini-pilla
when Combo OCPs and contraindicated or not tolerated
SE of emergency contraception
n/v breast tenderness
drugs in emergency contraception
levonorgestrel and ethinyl estradiol
drugs in plan B
levonorgesteral
OCP side effects
thromboit effects
MI
hypertension
cancer??
OCP + this is bad news
smoking
