PhysiologyTest 2 Flashcards
define antigen presentation
antigen presentation occurs when an antigen glycoprotein combination capable of activating T cells, appears in a plasma membrane. T cells sensitive to this antigen are activated if they contact the antigen on the plasma membrane of the antigen presenting cell
identify the 3 major types of T cells activated by class 1 MHC proteins
the 3 major types of t cells activated by class 1 MHC proteins are:
cytotoxic T cells
memory T cells
suppressor T cells
describe CD markers
T cell plasma membranes contain proteins called CD (cluster of differentiation) markers. cells with CD8 markers respond to antigens presented by class 1 MHC proteins and are on cytotoxic t cells. memory T cells and suppressor T cells with CD4 makers respond to class 2 MHC proteins
how can the presence of an abnormal antigen in the cytoplasm of a cell initiate an immune response
abnormal antigens in the cytoplasm of the cell can become attached to MCH proteins and displayed on the surface of plasma membrane. the recognition of such antigens by T cells initiate an immune response
define sensitization
sensitization is the process by which a B cell prepares to undergo activation so that it can subsequently react with a specific antigen
explain the function of cytokines secreted by helper T cells
cytokines secreted by activated T cells aid in coordinated specific and nonspecific defense and regulate cell mediated antibody mediated immunity
if you observe a higher than normal number of plasma cells in a sample of lymph would you expect antibody levels in the blood to be higher or lower than normal
plasma cells produce and secrete antibodies so observing an elevated number of plasma cells in the lymph would lead to expect higher than normal antibody levels in the blood
define allergy and allergen
an allergy is an inappropriate or excessive immune response to an allergen. an allergen is an antigen that triggers an allergic reaction
what is the anaphylaxis
in anaphylaxis an immune response to a circulating antigen stimulate mast cells throughout the body to release chemicals that prompt the inflammatory response
which chemicals do mast cels and basophils release when stimulated in an allergic reaction
histamines, leukotrienes, and other chemicals that cause pain, and inflammation are released when mast cells and basophils are stimulated in an allergic reaction
define Dalton’s law
Dalton’s law states that the in a mixture of gases. the individual gases exert a pressure proportional to their abundance in the mixture
what is the significance of Henry’s law to the process of respiration
Henry’s law states that, at a given T, the amount of a particular gas that dissolves in a liquid is directly proportional to the partial pressure of that gas. Henry’s law underlies the diffusion of gases between capillaries and alveoli, and between capillaries and interstitial fluid
define oxyhemoglobin
hemoglobin to which oxygen molecules have bound
explain the relationship among BPG, OXYGEN, AND HEMOGLOBIN
BPG is a compound that reduces hemoglobin’s affinity for oxygen. for any partial pressure of oxygen, if the concentration of BPG increase, the amount of oxygen released by hemoglobin will increase
during exercise, hemoglobin releases more oxygen to active skeletal muscles than it does when those muscles are at rest. why?
the combination of increased T and lower pH causes hemoglobin to release more oxygen that when the muscles are at rest. There is a lower pH because there is heat and acidic waste products generated by active skeletal muscles
normal interstitial fluid has a PO of what
40 mm Hg
define hemoglobin
molecule consisting of four globular protein subunits, each containing a heme unit. can reversibly bind up to four molecules of oxygen
what is CO and why can it be bad
gas released by petroleum-burning engines and heaters. it will irreversibly bind to units, making them unavailable for oxygen transport
what is hemoglobin saturation
the percentage of heme units containing bound oxygen at any given moment
RBCs do not contain mitochondria, so they can only generate ATP though what
glycolysis
RBCs do not contain mitochondria, so they can only generate ATP though what
glycolysis
the metabolic pathways involved in glycolysis also generate what
BPG
the metabolic pathways involved in glycolysis also generate what
BPG
the higher the concentration of BPG the ___ oxygen will be released by the Hb molecules
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