Physiology Review Slides Lec. 23

Question 1

% of Free CO2 in the Blood

Answer 1

7%

Question 2

How many ways can CO2 be transported in the blood?

Answer 2

3 Total

1. Free
2. CO2-Hgb
3. HCO3- (Bicarbonate)

Question 3

Haldane Effect

Answer 3

• The binding of O2 to Hemoglobin DISPLACES CO2 from the blood

Question 4

1dL of blood can carry what volume of O2?

Answer 4

20.1 mL

Question 5

1 gram of Hb can bind to what Volume of O2

Answer 5

1.34mL

Question 6

What Causes the O2-Heme curve shift to the RIGHT.

Answer 6

Increase in C.A.D.E.T.

C - CO2

A - Acid (decrease in pH, inc in H+)

D - 2,3 DPG (BPG)

E - Exercise

T - Temp

Question 7

Bohr Effect

Answer 7

• Increase in blood CO2 cause O2 to be DISPLACED from Hemoglobin
• Shifts O2-Hemoglobin dissociation curve to the RIGHT

Question 8

What happens when Hemoglobin increases in ACIDITY?

Answer 8

Releases H+

Question 9

How much Oxygen per dL gets transported to the Tissues?

Answer 9

19. 4 - 14.4 = 5

- 5ml O2/dL blood

Question 10

Normal [BPG]

Answer 10

• Keeps Dissociation Curve SLIGHTLY shifted to the Right at ALL times

Question 11

Because of the Physiological shunt, 22 mL of Hb/dL in the blood decreases to what?

Answer 11

19.4mL Hb/dL

Question 12

Because of the Physiological shunt, 15grams of Hb/dL in the blood decreases to what?

Answer 12

14.4 g/dL

Question 13

What is the Utilization Coefficient during Strenuous Exercise?

Answer 13

75-85%

Question 14

% of CO2 bound to Hemoglobin in the Blood

Answer 14

23%

Question 15

% of CO2 as Bicarbonate in the Blood

Answer 15

70%

Question 16

Why does CO2 get transported mostly as Bicarbonate in blood?

Answer 16

• Bicarbonate acts as a BUFFER

- Helps to maintain Physiological pH

Question 17

Utilization Coefficient

Answer 17

% of blood that GIVES up its Oxygen

• 25%

Question 18

Why does the displacing of CO2 occur when O2 binds to Hemoglobin?

Answer 18

• O2 makes Hemoglobin more ACIDIC

- More Acidic = Less tendency to bind to CO2